Probability Models for DNA Sequence Evolution

丛 书 名：Probability and Its Applications

版本说明：2nd ed. 2008

作     者：Richard Durrett 

I S B N：(纸本) 9780387781686 

出 版 社：Springer New York 

出 版 年：2008年

页      数：441页

学科分类：0710[理学-生物学] 02[经济学] 0202[经济学-应用经济学] 020208[经济学-统计学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0714[理学-统计学（可授理学、经济学学位）] 070103[理学-概率论与数理统计] 090102[农学-作物遗传育种] 0701[理学-数学] 

摘      要：Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability? To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from neutral evolution. The final chapter studies the evolution of whole genomes by chromosomal inversions, reciprocal translocations, and genome *** the book, the theory is developed in close connection with data from more than 60 experimental studies from the biology literature that illustrate the use of these results. This book is written for mathematicians and for biologists alike. We assume no previous knowledge of concepts from biology and only a basic knowledge of probability: a one semester undergraduate course and some familiarity with Markov chains and Poisson *** Durrett received his Ph.D. in operations research from Stanford University in 1976. He taught in the UCLA mathematics department before coming to Cornell in 1985. He is the author of six books and 125 research papers, and is the academic father of more than 30 Ph.D. students. His current interests are the use of probability models in genetics and ecology, and decreasing the mean and variance of his golf score.