Deep learning of the role of interleukin IL-17 and its action in promoting cancer

作     者：Nutini, Alessandro Sohail, Ayesha 

作者机构：Comsats Inst Informat Technol Dept Math Lahore 54000 Pakistan Ctr Study Motor Sci Biomech Dept Lucca Italy 

出 版 物：《BIO-ALGORITHMS AND MED-SYSTEMS》 (Bio-Algorithms Med-Syst.)

年 卷 期：2020年第16卷第4期

核心收录：

主　　题：bidimensional Ornstein-Uhlenbeck process deep learning immunotherapy interleukin-17 noise numerical algorithm 

摘      要：In breast cancer patients, metastasis remains a major cause of death. The metastasis formation process is given by an interaction between the cancer cells and the microenvironment that surrounds them. In this article, we develop a mathematical model that analyzes the role of interleukin IL-17 and its action in promoting cancer and in facilitating tissue metastasis in breast cancer, using a dynamic analysis based on a stochastic process that accounts for the local and global action of this molecule. The model uses the Ornstein-Uhlembeck and Markov process in continuous time. It focuses on the oncological expansion and the interaction between the interleukin IL-17 and cell populations This analysis tends to clarify the processes underlying the metastasis expansion mechanism both for a better understanding of the pathological event and for a possible better control of therapeutic strategies. IL-17 is a proinflammatory interleukin that acts when there is tissue damage or when there is a pathological situation caused by an external pathogen or by a pathological condition such as cancer. This research is focused on the role of interleukin IL-17 which, especially in the case of breast cancer, turns out to be a dominant communication pin since it interconnects with the activity of different cell populations affected by the oncological phenomenon. Stochastic modeling strategies, specially the Ornstein-Uhlenbeck process, with the aid of numerical algorithms are elaborated in this review. The role of IL-17 is discussed in this manuscript at all the stages of cancer. It is discussed that IL-17 also acts as metastasis promoter as a result of its proinflammatory nature. The stochastic nature of IL-17 is discussed based on the evidence provided by recent literature. The resulting dynamical analysis can help to select the most appropriate therapeutic strategy. Cancer cells, in the case of breast cancer, have high level of IL-17 receptors (IL-17R);therefore the interleukin itsel