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内蒙古自治区呼和浩特市赛罕区大学西街235号 邮编: 010021
作者机构:National Engineering Laboratory for Animal BreedingPlateau Animal Genetic Resources CenterChina Agricultural UniversityNo.2 Yuanmingyuan West RdHaidian DistrictBeijing 100193China Department of Poultry ScienceUniversity of Georgia303 Poultry Science BuildingAthensGA 30602USA
出 版 物:《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志(英文版))
年 卷 期:2021年第12卷第4期
页 面:1309-1322页
核心收录:
学科分类:0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖]
基 金:supported by the National Natural Science Foundation of China(31972532) the China Agricultural Research System(CARS-40-K05) the Innovation Base Cu
主 题:ceRNA Hypoxic adaptation Non-coding RNA Tibetan chicken Transcriptome
摘 要:Background:Tibetan chickens,a unique native breed in the Qinghai-Tibet Plateau of China,possess a suite of adaptive features that enable them to tolerate the high-altitude hypoxic *** evidence suggests that long non-coding RNAs(lncRNAs)and microRNAs(miRNAs)play roles in the hypoxic adaptation of high-altitude animals,although their exact involvement remains ***:This study aimed to elucidate the global landscape of mRNAs,lncRNAs,and miRNAs using transcriptome sequencing to construct a regulatory network of competing endogenous RNAs(ceRNAs)and thus provide insights into the hypoxic adaptation of Tibetan chicken *** total,354 differentially expressed genes(DE genes),389 differentially expressed lncRNAs(DE lncRNAs),and 73 differentially expressed miRNAs(DE miRNAs)were identified between Tibetan chickens(TC)and control Chahua chickens(CH).GO and KEGG enrichment analysis revealed that several important DE miRNAs and their target DE lncRNAs and DE genes are involved in angiogenesis(including blood vessel development and blood circulation)and energy metabolism(including glucose,carbohydrate,and lipid metabolism).The ceRNA network was then constructed with the predicted DE gene-DE miRNA-DE lncRNA interactions,which further revealed the regulatory roles of these differentially expressed RNAs during hypoxic adaptation of Tibetan ***:Analysis of transcriptomic data revealed several key candidate ceRNAs that may play high-priority roles in the hypoxic adaptation of Tibetan chickens by regulating angiogenesis and energy *** results provide insights into the molecular mechanisms of hypoxic adaptation regulatory networks from the perspective of coding and non-coding RNAs.