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The concept of molecular machinery is useful for design of stimuli-responsive gene delivery systems in the mammalian cell

作     者:Nagasaki, Takeshi Shinkai, Seiji 

作者机构:Department of Applied Chemistry and Bioengineering Graduate School of Engineering Osaka City University 3-3-138 Sugimoto Sumiyoshi-ku. Osaka 558-8585 Japan SORST Program Japan Science and Technology Corporation Kawaguchi. Saitama 332-0012 Japan Department of Chemistry and Biochemistry Graduate School of Engineering Kyushu University Fukuoka 819-0395 Japan Center for Future Chemistry Kyushu University Fukuoka 819-0395 Japan 

出 版 物:《Journal of Inclusion Phenomena and Macrocyclic Chemistry》 (J. Incl. Phenom. Macrocyclic Chem.)

年 卷 期:2007年第58卷第3-4期

页      面:205-219页

核心收录:

学科分类:0710[理学-生物学] 07[理学] 0817[工学-化学工程与技术] 070206[理学-声学] 080203[工学-机械设计及理论] 0703[理学-化学] 0802[工学-机械工程] 0836[工学-生物工程] 0701[理学-数学] 0702[理学-物理学] 

主  题:Ultrasonics 

摘      要:Since the first generation of molecular machines including photoresponsive crown ethers and its analogues was reported by Shinkai et al., a huge number of molecular machines exhibiting dynamic chemical and physical functions have been designed and developed. On the other hand, non-viral vectors are desired to possess conflicting properties to associate with DNA until reaching the nucleus as their final destination and dissociate from DNA there. In other words, non-viral vectors should work as a sort of molecular machinery. To overcome this dilemma, recently, much attention is focused on the development of the intelligent vectors, also called as stimuli responsive vectors working as molecular machines. In this review, stimulus responsive gene delivery systems in which some structural factors and/or physiological properties are regulated in response to extracellular signals such as redox, pH, ultrasound, light, temperature, etc. are introduced as a new generation of non-viral vectors. These extracellular signals such as ultrasound, light, and temperature can be potent stimuli capable of site-, timing-, and duration-specific gene expression. © Springer Science+Business Media B.V. 2007.

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