Green Electrospun Silk Fibroin Nanofibers Loaded with Cationic Ethosomes for Transdermal Drug Delivery

作     者：HONG Huoyan ZHANG Dongdong UN Si HAN Feng WANG Kaili JIANG Di WU Jinglei MO Xiumei WANG Hongsheng HONG Huoyan;ZHANG Dongdong;LIN Si;HAN Feng;WANG Kaili;JIANG Di;WU Jinglei;MO Xiumei;WANG Hongsheng

作者机构：Key Laboratory of Science&Technology of Eco-TextileMinistry of EducationShanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2021年第37卷第3期

页      面：488-495页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：This work was supported by the Project of the Science&Technology Commission of Shanghai Municipality China(Nos.18490740400 20DZ2254900) 

主　　题：Transdermal drug delivery Silk fibroin Ethosome Green electrospinning 

摘      要：Transdermal drug delivery system(TDDS)facilitates the controlled release of active ingredients penetrating through the skin,avoiding the liver first pass *** is a simple process to fabricate ultrafine fibers with a higher specific surface area,making them excellent candidates for drug *** current work,a novel silk fibroin(SF)nanofiber loaded with cationic ethosomes(CEs)was prepared via green *** data of Fourier transform infrared spectroscopy(FTIR)and laser scanning confocal microscopy(LSCM)confirmed the existence of CEs in the SF *** morphology of the nanofibers was not significantly affected by the incorporation of CEs as shown by scanning electron microscopy(SEM)*** CEs-loaded SF nanofibrous patch(CEs-SFnP)showed good cytocompatibility as proved by both cell counting Kit-8(CCK-8)assay and *** doxorubicin hydrochloride(Dox)as a model drug,the transdermal performance of CEs-SFnP was evaluated through Franz diffusion cell against mouse *** results indicated that CEs-SFnP can effectively deliver drug into the skin,with a much higher permeation rate than the normal nanofibers without *** as-spun CEs-SFnP in this study could find promising applications in TDDS.