Systemic delivery of microRNA for treatment of brain ischemia

作     者：Chaoyong Liu Jing Wen Dai Li Hongzhao Qi Lina Nih Jialin Zhu Duo Xu Yu Ren Shanshan Zhang Donglin Han Huanhuan Jia Junhu Zhou Meng Qin Jialing Wu Xubo Yuan Ji Liu Jin Zhao Chunsheng Kang Yunfeng Lu Chaoyong Liu;Jing Wen;Dai Li;Hongzhao Qi;Lina Nih;Jialin Zhu;Duo Xu;Yu Ren;Shanshan Zhang;Donglin Han;Huanhuan Jia;Junhu Zhou;Meng Qin;Jialing Wu;Xubo Yuan;Ji Liu;Jin Zhao;Chunsheng Kang;Yunfeng Lu

作者机构：Department of NeurosurgeryTianjin Medical University General HospitalTianjin 300052China Key Laboratory of Post-Trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjin Neurological InstituteTianjin 300052China College of Life Science and Technology and Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Department of Chemical and Biomolecular EngineeringUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA Department of MedicineTianjin Huanhu HospitalTianjin 300350China Tianjin Key Laboratory of Composite and Functional MaterialsSchool of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of MicrobiologyImmunology and Molecular GeneticsUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA Tianjin Research Center of Basic Medical ScienceTianjin Medical UniversityTianjin 300070China Department of NeurologyTianjin Huanhu HospitalTianjin 300350China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2021年第14卷第9期

页      面：3319-3328页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(No.2019YFA0903801) the National Natural Science Foundation of China(Nos.52073015,51773151,52003021,and 81671169) Tianjin Municipal Health Bureau(No.2010KY11) Postdoctoral Science Foundation of China(No.2015M580212) Fundamental Research Funds for the Central Universities(No.ZY2006) 

主　　题：polymer nanocapsules small RNA delivery microRNA-21 brain ischemia 

摘      要：Brain ischemia is the second leading cause of death and the third leading cause of disability in the *** delivery of microRNA,a class of molecules that regulate the expression of cellular proteins associated with angiogenesis,cell growth,proliferation and differentiation,holds great promise for the treatment of brain ***,their therapeutic efficacy has been hampered by poor delivery efficiency of *** report herein a platform technology based on microRNA nanocapsules,which enables their effective delivery to the disease sites in the *** by microRNA-21,intravenous injection of the nanocapsules into a rat model of cerebral ischemia could effectively ameliorate the infarct volume,neurological deficit and histopathological severity.