Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers

作     者：Ziyi Lu Yueming Wu Zihao Cong Yuxin Qian Xue Wu Ning Shao Zhongqian Qiao Haodong Zhang Yunrui She Kang Chen Hengxue Xiang Bin Sun Qian Yu Yuan Yuan Haodong Lin Meifang Zhu Runhui Liu 

作者机构：State Key Laboratory of Bioreactor EngineeringCollege of ChemistryChemical Engineering and Materials ScienceEast China University of Science and TechnologyShanghai200237China State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai201620China Jiangsu Key Laboratory of Advanced Functional Polymers Design and ApplicationSoochow UniversitySuzhou215123China Department of Orthopedic SurgeryShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Key Laboratory for Ultrafine Materials of Ministry of EducationFrontiers Science Center for Materiobiology and Dynamic ChemistryResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第12期

页      面：4531-4541页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：This research was supported by the National Natural Science Foundation of China(No.22075078,21774031) the National Key Research and Development Program of China(2016YFC1100401) Program of Shanghai Academic/Technology Research Leader(20XD1421400) State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,the Natural Science Foundation of Jiangsu Province(BK20180093) the Natural Science Foundation of Shanghai(18ZR1410300) Research program of State Key Laboratory of Bioreactor Engineering,the Fundamental Research Funds for the Central Universities(22221818014) The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization 

主　　题：Peptide polymer Host defense peptide Antimicrobial surface MRSA Subcutaneous infection 

摘      要：It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical *** defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant *** recent report on lithium hexamethyldisilazide-initiated superfast polymerization on amino acid N-carboxyanhydrides enables the quick synthesis of host defense peptide-mimicking peptide *** we reported a facile and cost-effective thermoplastic polyurethane(TPU)surface modification of peptide polymer(DLL:BLG=90:10)using plasma surface activation and substitution reaction between thiol and bromide *** peptide polymer-modified TPU surfaces exhibited board-spectrum antibacterial property as well as effective contact-killing ability in ***,the peptide polymer-modified TPU surfaces showed excellent biocompatibility,displaying no hemolysis and *** vivo study using methicillin-resistant Staphylococcus aureus(MRSA)for subcutaneous implantation infectious model showed that peptide polymer-modified TPU surfaces revealed obvious suppression of infection and great histocompatibility,compared to bare TPU *** further explored the antimicrobial mechanism of the peptide polymer-modified TPU surfaces,which revealed a surface contact-killing mechanism by disrupting the bacterial *** results demonstrated great potential of the peptide-modified TPU surfaces for practical application to combat bacterial infections that are associated with implantable materials and devices.