Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles:A panel study in Beijing,China

作     者：Ke Gao Xi Chen Xiaoying Li Hanxiyue Zhang Mengxiao Luan Yuan Yao Yifan Xu Teng Wang Yiqun Han Tao Xue Junxia Wang Mei Zheng Xinghua Qiu Tong Zhu Ke Gao;Xi Chen;Xiaoying Li;Hanxiyue Zhang;Mengxiao Luan;Yuan Yao;Yifan Xu;Teng Wang;Yiqun Han;Tao Xue;Junxia Wang;Mei Zheng;Xinghua Qiu;Tong Zhu

作者机构：State Key Joint Laboratory for Environmental Simulation and Pollution Control and Beijing Innovation Center for Engineering Science and Advanced TechnologyCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Green Research Inspection and Certification Co.Ltd.Institute of Building Research Co.Ltd.in ShenzhenShenzhen 518071China Medical Research CouncilCentre for Environment and HealthImperial College LondonDepartment of Epidemiology and BiostatisticsLondon W21PGUK Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health and Department of Epidemiology and BiostatisticsSchool of Public HealthPeking UniversityBeijing 100191China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2022年第65卷第2期

页      面：387-397页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070602[理学-大气物理学与大气环境] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0706[理学-大气科学] 10[医学] 

基　　金：the National Natural Science Foundation of China(41121004,21190051,41421064 and 81571130100) the National Basic Research Program of China(2015CB553401) 

主　　题：metal in fine particles chronic obstructive pulmonary disease(COPD) susceptibility heart rate cardiovascular auto-nomic function 

摘      要：Susceptibility of patients with chronic obstructive pulmonary disease(COPD)to cardiovascular autonomic dysfunction asso-ciated with exposure to metals in ambient fine particles(PM2.5,particulate matter with aerodynamic diameter≤2.5µm)remains poorly *** on the COPDB(COPD in Beijing)panel study,we aimed to compare the associations of heart rate(HR,an indicator of cardiovascular autonomic function)and exposure to metals in PM2.5 between 53 patients with COPD and 82 healthy controls by using linear mixed-effects *** all participants,the HR levels were significantly associated with interquartile range increases in the average concentrations of Cr,Zn,and Pb,but the strength of the associations differed by exposure time(from 1.4%for an average 9 days(d)Cr exposure to 3.5%for an average 9 d Zn exposure).HR was positively associated with the average concentrations of PM2.5 and certain metals only in patients with *** between HR and exposure to PM2.5,K,Cr,Mn,Ni,Cu,Zn,As,and Se in patients with COPD significantly differed from those in health ***,association between HR and Cr exposure was robust in COPD *** conclusion,our findings indicate that COPD could exacerbate difference in HR following exposure to metals in PM2.5.