Nidogen:A matrix protein with potential roles in musculoskeletal tissue regeneration

作     者：Sheng Zhou Song Chen Yixuan Amy Pei Ming Pei 

作者机构：Stem Cell and Tissue Engineering LaboratoryDepartment of OrthopaedicsWest Virginia UniversityMorgantownWV 26506USA Department of OrthopaedicsThe GeneraLHospital of Western Theater CommandChengduSichuan 610083PR China WVU Cancer InstituteRobert C.Byrd Health Sciences CenterWest Virginia UniversityMorgantownWV 26506USA 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2022年第9卷第3期

页      面：598-609页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：We thank Suzanne Danley for editing the manuscript.This work was supported by a Research Grant from the National Institutes of Health,USA(No.1R01AR067747)to M.P Health Commission of Sichuan Province(No.18PJ008) Science&Technology Department of Sichuan Province(No.2019YFS0267)to S.C 

主　　题：Adipose Basement membrane Cartilage Differentiation Nerve Nidogens Vessel 

摘      要：Basement membrane proteins are known to guide cell structures,differentiation,and tissue *** there is a wealth of knowledge on the functions of laminins,per-lecan,and type IV collagen in maintaining tissue homeostasis,not much is known about *** a key molecule in the basement membrane,nidogen contributes to the formation of a delicate microenvironment that proves necessary for stem cell lineage-specific *** this review,the expression of nidogen is delineated at both cellular and tissue levels from embryonic to adult stages of development;the effect of nidogens is also summarized in the context of musculoskeletal development and regeneration,including but not limited to adipogenesis,angiogenesis,chondrogenesis,myogenesis,and ***,potential mechanisms underlying the role of nidogens in stem cell-based tissue regeneration are also *** concise review is expected to facilitate our existing understanding and utilization of nidogen in tissue engineering and regeneration.