Injectable Hyaluronic Acid/Poly(y-glutamic acid)Hydrogel with Step-by-step Tunable Properties for Soft Tissue Engineering

作     者：Xue-Bin Ma Rong Yang Kanaparedu P.C.Sekhar Bo Chi Xue-Bin Ma;Rong Yang;Kanaparedu P.C.Sekhar;Bo Chi

作者机构：Key Laboratory of Colloid and Interface Chemistry of the Ministry of EducationSchool of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China State Key Laboratory of Materials-Oriented Chemical EngineeringCollege of Food Science and Light IndustryNanjing Tech UniversityNanjing 211816China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2021年第39卷第8期

页      面：957-965,I0005页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the National Natural Science Foundation of China(No.31771049) Foundation of key R&D Project of Jiangsu Province(No.BE2018731) Research Foundation of State Key Laboratory of Materials-Oriented Chemical Engineering(Nos.ZK201806 and No.KLI 8-06) the Six Talent Peaks Project of Jiangsu Province(No.SWYY-046) 

主　　题：Hyaluronic acid Poly(y-glutamic acid) Injectable hydrogel Tissue engineering 

摘      要：Injectable hydrogels as an important class of biomaterials have gained much attention in tissue ***,their crosslinking degree is difficult to be controlled after being injected into *** we all know,the crosslinking degree strongly influences the physicochemical properties of ***,developing an injectable hydrogel with tunable crosslinking degree in vivo is important for tissue ***,we present a dual crosslinking strategy to prepare injectable hydrogels with step-by-step tunable crosslinking degree using Schiff base reaction and *** developed hyaluronic acid/poly(y-glutamic acid)(HA/y-PGA)hydrogels exhibit step-by-step tunable swelling behavior,enzymatic degradation behavior and mechanical *** performance tests show that the storage moduli of HA/y-PGA hydrogels are all less than 2000 Pa and the compressive moduli are in kilopascal,which have a good match with soft *** addition,NIH 3T3 cells encapsulated in HA/y-PGA hydrogel exhibit a high cell viability,indicating a good cytocompatibility of HA/y-PGA ***,the developed HA/y-PGA hydrogel as an injectable biomaterial has a good potential in soft tissue engineering.