Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode

作     者：Gilar Wisnu Hardi Siti Fauziyah Rahman 

作者机构：Biomedical Engineering Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 

出 版 物：《AIP Conference Proceedings》 

年 卷 期：2021年第2344卷第1期

学科分类：07[理学] 0702[理学-物理学] 

摘      要：Abnormal concentrations of dopamine in extracellular fluid are associated with a variety of diseases, such as Parkinson’s disease. It, therefore, plays a critical role in the quantitative analysis of dopamine in body fluids in the control of biological drugs as well as in the clinical diagnostic field. Poly (3,4-ethylenedioxythiophene)-(Poly(4-styrenesulfonate)) was successfully fabricated on the surface of the glassy carbon electrode by electrochemical method and used to determine dopamine. The oxidation peaks of dopamine had higher sensitivity at PEDOT-PSS modified electrode in phosphate buffer solution (PBS, pH 6.0). The electrocatalytic activity of the corresponding dopamine electrodes was investigated using cyclic voltammetry (CV) and indicated that PEDOT: PSS by electropolymerization modified had a much higher electrocatalytic oxidation activity for dopamine than any other method. The results obtained have shown that PEDOT: PSS is a promising candidate for the modification of electrode material used in electrochemical sensing and other electrocatalytic applications.