A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy

作     者：Huanhuan Wang Xiaohong Pan Yaqi Wang Wenzhen Liu Tao Dai Binbin Yuan Xueyuan Chen Zhuo Chen 王欢欢;潘小宏;王亚琪;刘雯珍;戴涛;袁彬彬;陈学元;陈卓

作者机构：State Key Laboratory of Structural ChemistryCAS Key Laboratory of Design and Assembly of Functional NanostructuresFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2021年第64卷第10期

页      面：2601-2612页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (81572944 and 81971983) the CAS/ SAFEA International Partnership Program for Creative Research Teams the High-Level Entrepreneurship and Innovation Talents Projects in Fujian Province (2018-8-1) the FJIRSM&IUE Joint Research Fund (RHZX-2018-004) 

主　　题：photodynamic antibacterial therapy photosensitizer aggregation-induced emission reactive oxygen species imaging 

摘      要：hotodynamic therapy(PDT)has been drawing more and more attention in the antibacterial *** photosensitizers(PSs)tend to aggregate in aqueous media,which reduces the generation of reactive oxygen species(ROS)and seriously affects the photodynamic *** efforts have been made to prevent aggregation of traditional *** contrast,aggregation-induced emission PSs(AIE-PSs)take advantage of aggregation to boost ROS generation and fluorescence ***,the efficacies of the reported antibacterial AIE-PSs are ***,we report a new class of highly effective antibacterial AIE-PSs based on nitrobenzoic acid ***,a negatively charged AIE-PS,can not only selectively kill spherical bacteria(Staphylococcus aureus(***))rather than rod-shaped bacteria(Escherichia coli(***)),but also be easily extended to several AIE-PSs(TTVBP1–3)with positive charges and broad-spectrum antibacterial *** demonstrate that TTVBP2 can kill3.0 log_(10)of *** at very low concentration(125 nmol L^(-1)),TTVBP3 can kill 4.7 log_(10)of Staphylococcus epidermidis(***)at a concentration of 1μmol L^(-1)and 3.8 log_(10)of *** at 5μmol L^(-1),thus enabling them among the most effective antibacterial AIE-PSs reported so ***,these AIE-PSs exhibit excellent wash-free imaging ability for bacteria by simple mixing with *** thus envision that TTVBA,a nitrobenzoic acid-based extendable AIE-PS,provides a new route for the design of AIE-PSs in antibacterial treatment.