Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori

作     者：Jiangbo Song Lian Liu Kaige Hao Shuang Mao Yongxi Tang Xiaoling Tong Fangyin Dai Jiangbo Song;Lian Liu;Kaige Hao;Shuang Mao;Yongxi Tang;Xiaoling Tong;Fangyin Dai

作者机构：State Key Laboratory of Silkworm Genome BiologyKey Laboratory for Sericulture Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest UniversityNo.2 Tiansheng RoadBeibei DistrictChongqing400715China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2021年第11卷第3期

页      面：374-382页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.31830094 and 31902215) the Hi-Tech Research and Development 863 Program of China(Grant No.2013AA102507) the Fundamental Research Funds for the Central Universities in China(No.XDJK2019C014) Project funded by Chongqing Special Postdoctoral Science Foundation(Grant No.XmT2018058) Funds of China Agricultural Research System(No.CARS-18-ZJ0102) 

主　　题：Resveratrol Bombyx mori Lifespan Antioxidant activity SIRT7-FoxO-GST pathway 

摘      要：A number of research has shown that the plant polyphenol resveratrol,one of the most prominent small molecules,has beneficial protective effects in multiple organisms,including worms,flies,and *** understand the effects of resveratrol on lifespan,we evaluated its effects in the silkworm Bombyx *** this study,we found that lifespan was significantly prolonged in both female and male silkworms treated with *** larval weight was significantly increased from day 3 of the 5th larval instar(L5D3)to day 7 of the 5th larval instar(L5D7).However,the weight of the pupa,cocoon,and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in ***,resveratrol significantly improved the thermotolerance of the silkworms,which enhanced their survival ***,antioxidant activity was increased by resveratrol in both female and male ***,an antioxidant-related signalling pathway,SIRT7-FoxO-GST,was activated in silkworms with resveratrol ***,these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs.