Control of synthetic microbial consortia in time, space, and composition

作     者：Grandel, Nicolas E. Reyes Gamas, Kiara Bennett, Matthew R. 

作者机构：Graduate Program in Systems Synthetic and Physical Biology Rice University Houston TX United States Department of Biosciences Rice University Houston TX United States Department of Bioengineering Rice University Houston TX United States 

出 版 物：《Trends in Microbiology》 (Trends Microbiol.)

年 卷 期：2021年第29卷第12期

页      面：1095-1105页

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071005[理学-微生物学] 10[医学] 

主　　题：control microbial consortia synthetic biology 

摘      要：While synthetic microbial systems are becoming increasingly complicated, single-strain systems cannot match the complexity of their multicellular counterparts. Such complexity, however, is much more difficult to control. Recent advances have increased our ability to control temporal, spatial, and community compositional organization, including modular adhesive systems, strain growth relationships, and asymmetric cell division. While these systems generally work independently, combining them into unified systems has proven difficult. Once such unification is proven successful we will unlock a new frontier of synthetic biology and open the door to the creation of synthetic biological systems with true multicellularity. © 2021 Elsevier Ltd