Effects of socioeconomic status in cognition of people with schizophrenia: results from a Latin American collaboration network with 1175 subjects

作     者：Czepielewski, Leticia Sanguinetti Maria Alliende, Luz Paz Castaneda, Carmen Castro, Mariana Guinjoan, Salvador M. Massuda, Raffael Berberian, Arthur A. Fonseca, Ana Olivia Gadelha, Ary Bressan, Rodrigo Crivelaro, Marisa Louza, Mario Undurraga, Juan Gonzalez-Valderrama, Alfonso Nachar, Ruben Nieto, Rodrigo R. Montes, Cristian Silva, Hernan Langer, Alvaro, I Schmidt, Carlos Mayol-Troncoso, Rocio Diaz-Zuluaga, Ana M. Valencia-Echeverry, Johanna Lopez-Jaramillo, Carlos Solis-Vivanco, Rodolfo Reyes-Madrigal, Francisco de la Fuente-Sandoval, Camilo Crossley, Nicolas A. Gama, Clarissa S. 

作者机构：Hosp Clin Porto Alegre Ctr Pesquisa Clin Lab Mol Psychiat Porto Alegre RS Brazil Univ Fed Rio Grande do Sul UFRGS Inst Psicol Programa Posgrad Psicol Porto Alegre RS Brazil Pontificia Univ Catolica Chile Sch Med Dept Psychiat Santiago Chile Inst Psiquiatr Dr J Horwitz Barak Early Intervent Program Santiago Chile FLENI CONICET Neurosci Inst Res Grp Neurosci Appl Abnormal Behav INAAC Grp Buenos Aires DF Argentina Univ Buenos Aires Dept Psychiat & Mental Hlth Sch Med Fleni Teaching Unit Buenos Aires DF Argentina Univ Buenos Aires Dept Physiol Sch Med Buenos Aires DF Argentina Univ Buenos Aires CONICET Fleni Teaching Unit Dept Psychiat & Mental HlthSch Med Buenos Aires DF Argentina Univ Fed Parana UFPR Dept Psiquiatria Curitiba Parana Brazil Univ Fed Sao Paulo Sao Paulo Brazil Univ Fed Sao Paulo Univ Fed Sao Paulo PROESQ EPM UNIFESP Programa Esquizofrenia Escola Paulista Med Sao Paulo Brazil Inst Psiquiatria HCFMUSP PROJESQ Programa Esquizofrenia Sao Paulo Brazil Clin Alemana Univ Desarrollo Fac Med Dept Neurol & Psychiat Santiago Chile Univ Finis Terrae Sch Med Santiago Chile Univ Chile Univ Psychiat Clin Clin Hosp Santiago Chile Univ Chile Fac Med Dept Psychiat & Mental Hlth Santiago Chile Univ Chile Fac Med Dept Neurosci Santiago Chile Univ Austral Chile Fac Med Inst Estudios Psicol Valdivia Chile Univ Austral Chile Ctr Interdisciplinary Studies Nervous Syst CISNe Valdivia Chile Millennium Nucleus Improve Mental Hlth Adolescent Santiago Chile Millennium Inst Res Depress & Personal MIDAP Santiago Chile Univ Barcelona Brain Cognit & Behav PhD Program Barcelona Spain Univ Antioquia Fac Med Dept Psychiat Res Grp Psychiat GIPSI Medellin Colombia Inst Nacl Neurol & Neurocirug Lab Neuropsychol Mexico City DF Mexico Inst Nacl Neurol & Neurocirug Lab Expt Psychiat Mexico City DF Mexico Inst Nacl Neurol & Neurocirug Neuropsychiat Dept Mexico City DF Mexico Pontificia Univ Catolica Chile Biomed Imaging Ctr Santiago Chile Pontificia Univ Catolica Chile Ctr Integrat Neurosci Santiago Chile Kings Coll London Inst Psychiat Psychol & Neurosci Dept Psychosis Studies London England Univ Fed Rio Grande do Sul Grad Program Psychiat & Behav Sci Porto Alegre RS Brazil 

出 版 物：《PSYCHOLOGICAL MEDICINE》 (心理医学)

年 卷 期：2022年第52卷第11期

页      面：2177-2188页

核心收录：

学科分类：0402[教育学-心理学(可授教育学、理学学位）] 1002[医学-临床医学] 10[医学] 

基　　金：ARGENTINA - Agencia de Promocion [PICT-2014-0633] BRAZIL - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [Fapesp 2010/10788-6] CHILE - Agencia Nacional de Investigacion y Desarrollo (ANID) Anillo [ACT1414, ACT192064] FONDECYT [1180358, 1200601, 3190790] XII Concurso Nacional de Proyectos de Investigacion y Desarrollo en Salud, FONIS 2015 Proyecto , Ministerio de Economia, Chile [SA15I20058] Biomedical Neuroscience Institute [ICM P09-015F] ANID FONDECYT ANID - Millennium Science Initiative COLOMBIA - PRISMA UNION TEMPORAL (UNIVERSIDAD DE ANTIOQUIA / HOSPITAL SAN VICENTE FUNDACION) Colciencias-INVITACION MEXICO - Instituto Nacional de Neurologia y Neurocirugia: Consejo Nacional de Ciencia y Tecnologia, Mexico, (CONACyT) [261987, 261895] National Institutes of Health [R21 MH102374] CONACyT 

主　　题：Cognition low- and middle-income countries schizophrenia social factors 

摘      要：Background Cognition heavily relies on social determinants and genetic background. Latin America comprises approximately 8% of the global population and faces unique challenges, many derived from specific demographic and socioeconomic variables, such as violence and inequality. While such factors have been described to influence mental health outcomes, no large-scale studies with Latin American population have been carried out. Therefore, we aim to describe the cognitive performance of a representative sample of Latin American individuals with schizophrenia and its relationship to clinical factors. Additionally, we aim to investigate how socioeconomic status (SES) relates to cognitive performance in patients and controls. Methods We included 1175 participants from five Latin American countries (Argentina, Brazil, Chile, Colombia, and Mexico): 864 individuals with schizophrenia and 311 unaffected subjects. All participants were part of projects that included cognitive evaluation with MATRICS Consensus Cognitive Battery and clinical assessments. Results Patients showed worse cognitive performance than controls across all domains. Age and diagnosis were independent predictors, indicating similar trajectories of cognitive aging for both patients and controls. The SES factors of education, parental education, and income were more related to cognition in patients than in controls. Cognition was also influenced by symptomatology. Conclusions Patients did not show evidence of accelerated cognitive aging;however, they were most impacted by a lower SES suggestive of deprived environment than controls. These findings highlight the vulnerability of cognitive capacity in individuals with psychosis in face of demographic and socioeconomic factors in low- and middle-income countries.