3D Printing Bioink Preparation and Application in Cartilage Tissue Reconstruction in Vitro

作     者：SUN Binbin HAN Yu JIANG Wenbo DAI Kerong 孙彬彬;韩煜;姜闻博;戴尅戎

作者机构：Department of Orthopaedic SurgeryShanghai Key Laboratory of Orthopaedic ImplantsClinical and Translational Research Center for 3D Printing TechnologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China 

出 版 物：《Journal of Shanghai Jiaotong university(Science)》 (上海交通大学学报（英文版）)

年 卷 期：2021年第26卷第3期

页      面：267-271页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the National Key Research and Development Program of China(Nos.2018YFB1105600,and 2018YFA0703000) the National Natural Science Foundation of China(No.81802131) the China Postdoctoral Science Foundation(No.2019T120347) 

主　　题：bioink cartilage 3D printing tissue engineering biomaterials 

摘      要：Three-dimensional(3D)bioprinting technology has great potential for application in the treatment of cartilage ***,the preparation of biocompatible and stable bioinks is still a major *** this study,decellularized extracellular matrix(dECM)of soft tissue was used as the basic material to prepare the *** results showed that this novel dECM-derived bioink had good printing performance and comprised a large number of fine *** characterization revealed that the bioink was compatible with the growth of chondrocytes and that the nanofibrous structure greatly promoted cell *** and immunohistochemical analyses showed that the in vitro printed cartilage displayed the presence of characteristic cartilage ***,a new preparation method for dECM-derived bioink with potential application in generation of cartilage was developed in this study.