2494. Influenza B Hospitalizations Are Associated With Mortality in Children, FluSurv-NET, 2011–2017

作     者：Shikha Garg Alissa O’Halloran Charisse Nitura Cummings Shua J Chai Nisha Alden Kimberly Yousey-Hindes Evan J Anderson Patricia Ryan James Collins Chad Smelser Debra Blog Christina B Felsen Laurie Billing Ann Thomas H Keipp Talbot Melanie Spencer Ruth Lynfield Carrie Reed 

作者机构：Influenza Division Centers for Disease Control and Prevention Atlanta Georgia Assigned to the California Department of Public Health US Centers for Disease Control (CDC) Richmond California Colorado Department of Public Health and Environment Denver Colorado Connecticut Emerging Infections Program Yale School of Public Health New Haven Connecticut Emerging Infections Program Atlanta Veterans Affairs Medical Center Atlanta Georgia MD Dept Health Mental Hygiene Baltimore Maryland Michigan Department of Health and Human Services Lansing Michigan New Mexico Emerging Infections Program Santa Fe New Mexico Bureau of Immunization New York State Department of Health Albany New York NY Emerging Infections Program Center for Community Health and Prevention University of Rochester Medical Center Rochester New York Ohio Department of Health Columbus Ohio Oregon Public Health Division Portland Oregon Infectious Diseases Vanderbilt University Medical Center Nashville Tennessee Salt Lake County Health Department Salt Lake City Utah State Epidemiologist and Medical Director for Infectious Diseases Epidemiology & Community Health Minnesota Department of Health St. Paul Minnesota 

出 版 物：《Open Forum Infect Dis》 

年 卷 期：2018年第5卷第SUPPL 1期

页      面：S748-S748页

摘      要：Background Influenza B viruses (B) co-circulate with influenza A viruses (A) and contribute to influenza-associated hospitalizations each season. We used data from the Influenza Hospitalization Surveillance Network (FluSurv-NET) to determine the association between B virus hospitalizations and mortality among children. Methods We included data from children aged 0–17 years, residing in a FluSurv-NET catchment area, and hospitalized with laboratory-confirmed influenza during 2011–2012 through 2016–2017. We abstracted data on underlying conditions, clinical course and outcomes from medical charts. After excluding cases with unknown influenza type or with A/B coinfection, we compared characteristics of children hospitalized with A vs. B using univariate analyses and multivariable logistic regression, to determine the independent association between virus type and in-hospital mortality. Results Among 7671 children hospitalized with influenza, 5607 (73%) had A and 2064 (27%) had B. The proportion of B hospitalizations varied by season from 11% during 2013–2014 to 42% during 2012–2013. Among children with B, median age was 4 years (interquartile range 1–8 years), 58% were male and 36% were non-Hispanic white. In univariate analysis, children with B were more likely to be older, have cardiovascular and neurologic disease, to be vaccinated (38 vs. 32%), and to be hospitalized ≥2 days after illness onset, and were less likely to have asthma and receive antivirals (71 vs. 79%) compared with those with A ( P 0.05). There were no differences in the proportion with ≥1 underlying condition (59% both groups). Patients with B vs. A were no more likely to require intensive care (19 vs. 20%; p 0.34) or receive mechanical ventilation (6 vs. 5%; p 0.13); however, patients with B were more likely to die in-hospital (1 vs. 0.4%; P 0.01). The unadjusted odds of in-hospital mortality for children with B vs. A was 2.3 (95% confidence interval (CI) 1.3–4.1), which remained elevated at 2.