Chemical constituents of two Cameroonian medicinal plants: <i>Sida rhombifolia</i> L. and <i>Sida acuta</i> Burm. f. (Malvaceae) and their antiplasmodial activity

作     者：Kamdoum, Blaise Cedric Simo, Ingrid Wouamba, Steven Collins Njonte Tchatat Tali, Brice Mariscal Ngameni, Bathelemy Fotso, Ghislain Wabo Ambassa, Pantaleon Fabrice, Fekam Boyom Lenta, Bruno Ndjakou Sewald, Norbert Ngadjui, Bonaventure Tchaleu 

作者机构：Univ Yaounde I Dept Organ Chem Fac Sci Yaounde Cameroon Univ Dschang Dept Chem Fac Sci Dschang Cameroon Univ Yaounde I Higher Teacher Training Coll Dept Chem Yaounde Cameroon Univ Yaounde I Dept Biochem Fac Sci Yaounde Cameroon Univ Yaounde I Fac Med & Biomed Sci Dept Pharm Yaounde Cameroon Bielefeld Univ Organ & Bioorgan Chem Fac Chem Bielefeld Germany 

出 版 物：《NATURAL PRODUCT RESEARCH》 (天然产物通讯)

年 卷 期：2022年第36卷第20期

页      面：5311-5318页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 0703[理学-化学] 

基　　金：DAAD Federal Ministry for Economic Cooperation and Development (BMZ) through the YaBiNaPA project 

主　　题：Sida rhombifolia L Sida acuta Burm f Malvaceae rhombifoliamide xylitol dimer antiplasmodial activities 

摘      要：An extensive phytochemical investigation of the EtOH/H2O (7:3) extracts of Sida rhombifolia L. and Sida acuta Burm. f., yielded a previously undescribed ceramide named rhombifoliamide (1) and a xylitol dimer (2), naturally isolated here for the first time, as well as the thirteen known compounds viz, oleanolic acid (3), beta-amyrin glucoside (4), ursolic acid (5), beta-sitosterol glucoside (6), tiliroside (7), 1,6-dihydroxyxanthone (8), a mixture of stigmasterol (9) and beta-sitosterol (10), cryptolepine (11), 20-Hydroxyecdysone (12), (E)-suberenol (13), thamnosmonin (14) and xanthyletin (15). Their structures were elucidated by the analyses of their spectroscopic and spectrometric data (1 D and 2 D NMR, and HRESI-MS) and by comparison with the previously reported data. The crude extracts, fractions, and some isolated compounds were tested against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains. All the tested samples demonstrated moderate and/or significant activities against 3D7 (IC50 values: 0.18-20.11 mu g/mL) and Dd2 (IC50 values: 0.74-63.09 mu g/mL).