Modeling and simulation of the“IL-36 cytokine”and CAR-T cells interplay in cancer onset

作     者：Khaled A.A-Utaibi Alessandro Nutini Ayesha Sohail Robia Arif Sumeyye Tunc Sadiq M.Sait 

作者机构：Computer Science and Software Engineering Department University of Ha’ilHa’ilSaudi Arabia Biology and Biomechanics Department Centro Studi Attivita Motorie via di Tiglio94 LuccaItaly Department of Mathematics Comsats University IslamabadLahore 54000Pakistan Vocational School of Sciences Physiotherapy ProgrammeMedipol University UnkapanıAtat¨urk BulvarıNo.27Halic Campus34083 FatihIstanbulTurkey Center for Communications and IT Research Research InstituteKing Fahd University of Petroleum&Minerals Dhahran 31261Saudi Arabia 

出 版 物：《International Journal of Modeling, Simulation, and Scientific Computing》 (建模、仿真和科学计算国际期刊（英文）)

年 卷 期：2022年第13卷第3期

页      面：207-222页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：IL-36 bone remodeling mathematical model BMUs CAR-T cells 

摘      要：Background:CAR-T cells are chimeric antigen receptor(CAR)-T cells;they are targetspecific engineered cells on tumor cells and produce T cell-mediated antitumor ***-T cell therapy is the“first-linetherapy in immunotherapy for the treatment of highly clonal neoplasms such as lymphoma and *** adoptive therapy is currently being studied and tested even in the case of solid tumors such as osteosarcoma since,precisely for this type of tumor,the use of immune checkpoint inhibitors remained *** CAR-T is a promising therapeutic technique,there are therapeutic limits linked to the persistence of these cells and to the tumor’s immune ***-T cell engineering techniques are allowed to express interleukin IL-36,and seem to be much more efficient in antitumoral ***-36 is involved in the long-term antitumor action,allowing CAR-T cells to be more efficient in their antitumor action due to a“cross-talkaction between the“IL-36/dendritic cellsaxis and the adaptive ***:This analysis makes the model useful for evaluating cell dynamics in the case of tumor relapses or specific understanding of the action of CAR-T cells in certain types of *** model proposed here seeks to quantify the action and interaction between the three fundamental elements of this antitumor activity induced by this type of adoptive immunotherapy:IL-36,“armoredCAR-T cells(i.e.,engineered to produce IL-36)and the tumor cell population,focusing exclusively on the action of this interleukin and on the antitumor consequences of the so modified CAR-T *** model was developed and numerical simulations were carried out during this *** development of the model with stability analysis by conditions of Routh–Hurwitz shows how IL-36 makes CAR-T cells more efficient and persistent over time and more effective in the antitumoral treatment,making therapy more effective against the“solid tumor.Findings:Primary malignant bone tumors are