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作者机构:State Key Laboratory of Rice Biology&Ministry of Agricultural and Rural Affairs Laboratory of Molecular Biology of Crop Pathogens and InsectsInstitute of Pesticide and Environmental ToxicologyZhejiang UniversityHangzhou 310058China Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang ProvinceCollege of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Institute of Environmental BiotechnologyGraz University of TechnologyPetersgasse 128010 GrazAustria Global Education Program for AgriScience FrontiersGraduate School of AgricultureHokkaido UniversitySapporo 0608589Japan State Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural UniversityNanjing 210095China Ecology and Environmental Sciences CenterSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China Key laboratory of South Subtropical Fruit Biology and Genetic Resource Uilization(MOA)Instiute of Fruit Tree ResearchGuangdong Acadermy of Agricultural SciencesGuangzhou 510640China Tea Research InstiuteChinese Academy of Agriculural SciencesHangzhou 310008China Shanghai Intermnational Studies UniversityShanghai 200083China Xiaoshan Agricultural Comprehensive Development Zone&Management CommitteeHangzhou 311200China
出 版 物:《Fundamental Research》 (自然科学基础研究(英文版))
年 卷 期:2022年第2卷第2期
页 面:198-207页
基 金:This work was supported by the National Natural Science Foundation of China(Grants No.32122074,31501684) National Key Research and Development Program of China(Grants No.2021YFE0113700,2017YFD0202100,2017YFE0102200) Zhejiang Provincial Natural Science Foundation of China(Grant No.LQ16C140001) Zhejiang Provincial Key Research and Development Program of China(Grant No.2015C02019) Strategic Research on“Plant Microbiome and Agroecosystem Health”(Grant No.2020ZL008 Cao Guangbiao High Science and Technology Foundation,Zhejiang University) the Fundamental Research Funds for the Central Universities(Grant No.2021FZZX001-31,Zhejiang University)
主 题:Phytopathogen Virulence factor Transcriptome reprogramming Agrochemical Pesticide Rice
摘 要:Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host s defense *** employing this strategy are currently threatening global rice *** the present study,variations in the virulence of the highly destructive Barkholderiaplantarii were observed in different rice-producing *** environment-linked variation was not attributable to any known host-related or external ***-occurrence analyses indicated a connection between reduced virulence and 5-Amino-l,3,4-thiadiazole-2-thiol(ATT),a non-bactericidal organic ***,which accumulates in rice plants during metabolization of specific agrochemicals,was found to reduce virulence factor secretion by *** up to 88.8%and inhibit pathogen virulence by hijacking an upstream signaling *** assessment of the newly discovered virulence inhibitor resulted in mechanistic insights into positive effects of ATT accumulation in plant *** of virulence alleviation were deciphered by integrating high-throughput data,gene knockout mutants,and molecular interaction ***,a histidine protein kinase in a two-component system that regulates virulence factor secretion,is likely the molecular target antagonized by *** findings provide novel insights into virulence modulation in an important plant-pathogen system that relies on the host s metabolic activity and subsequent signaling interference.