Prediction of pulmonary hypertension using central-to-peripheral pulmonary vascular volume ratio on three-dimensional cardiothoracic CT in patients with congenital heart disease

作     者：Goo, Hyun Woo Park, Sang Hyub 

作者机构：Univ Ulsan Asan Med Ctr Dept Radiol Coll Med 88Olymp Ro 43 Gil Seoul 05505 South Korea Univ Ulsan Asan Med Ctr Res Inst Radiol Coll Med 88Olymp Ro 43 Gil Seoul 05505 South Korea 

出 版 物：《JAPANESE JOURNAL OF RADIOLOGY》 (放射医学)

年 卷 期：2022年第40卷第9期

页      面：961-969页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 1009[医学-特种医学] 10[医学] 100602[医学-中西医结合临床] 

主　　题：Computed tomography angiography Computer-assisted image processing Congenital heart defects Echocardiography Pulmonary hypertension 

摘      要：Purpose To evaluate whether the central-to-peripheral pulmonary vascular volume ratio measured using three-dimensional cardiothoracic CT can serve as a potential predictor of pulmonary hypertension (PH) in patients with congenital heart disease. Methods Cardiothoracic CT was used to quantify right and left total, central, and peripheral pulmonary vascular volumes segmented based on a three-dimensional threshold-based approach in 60 patients with congenital heart disease (group with PH, n = 30;group without PH, n = 30). The CT-based central-to-peripheral pulmonary vascular volume ratios were correlated with the echocardiography-based maximum velocity of tricuspid regurgitation (TR Vmax) and systolic pulmonary arterial pressure (PAP) values. The diagnostic ability of the central-to-peripheral pulmonary vascular volume ratio to predict PH was analyzed. Results The central-to-peripheral pulmonary vascular volume ratios were significantly higher in the group with PH compared to the group without PH (1.6 +/- 0.9 vs. 0.8 +/- 0.3 for the right side, p 0.001;2.4 +/- 2.2 vs. 1.0 +/- 1.4 for the left side, p 0.004). The right central-to-peripheral pulmonary volume ratios were significantly positively correlated with the TR Vmax and estimated systolic PAP values (R = 0.627 and 0.633, respectively;p 0.001) in patients with and without PH, while the ratios were moderately correlated with the TR Vmax and estimated systolic PAP values (R = 0.431 and 0.435, respectively;p 0.020) in the group with PH. The right and left central-to-peripheral pulmonary vascular volume ratios demonstrated a good diagnostic ability for predicting the presence of PH (area under the receiver-operating characteristic curve = 0.867, p 0.001 and 0.859, p 0.001 for the right and left, respectively). Conclusion The CT-based central-to-peripheral pulmonary vascular volume ratio can be used to predict PH in patients with congenital heart disease.