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arXiv

Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions

作     者:Gautam, Rekha Xiang, Yinxiao Lamstein, Josh Liang, Yi Bezryadina, Anna Liang, Guo Hansson, Tobias Wetzel, Benjamin Preece, Daryl White, Adam Silverman, Matthew Kazarian, Susan Xu, Jingjun Morandotti, Roberto Chen, Zhigang 

作者机构:Department of Physics and Astronomy San Francisco State University San FranciscoCA94132 United States Department of Biomedical Engineering Vanderbilt University NashvilleTN37240 United States MOE Key Lab of Weak-Light Nonlinear Photonics TEDA Applied Physics Institute School of Physics Nankai University Tianjin300457 China Guangxi Key Lab for Relativistic Astrophysics Guangxi Colleges Universities Key Lab of Novel Energy Materials and Related Technology School of Physical Science and Technology Guangxi University Nanning Guangxi530004 China Department of Physics and Astronomy California State University Northridge NorthridgeCA91330 United States Institut National de la Recherche Scientifique Université du Québec VarennesQCJ3X 1S2 Canada Department of Physics Chemistry and Biology Linköping University LinköpingSE-581 83 Sweden School of Mathematical and Physical Sciences University of Sussex Sussex House Falmer BrightonBN1 9RH United Kingdom Department of Biomedical Engineering University of California Irvine IrvineCA United States Clinical Laboratory Science Program San Francisco State University San FranciscoCA94132 United States Institute of Fundamental and Frontier Sciences University of Electronic Science and Tech. of China Chengdu610054 China ITMO University Saint Petersburg197101 Russia 

出 版 物:《arXiv》 (arXiv)

年 卷 期:2019年

核心收录:

主  题:Nonlinear optics 

摘      要:Osmotic conditions play an important role in the cell properties of human red blood cells (RBCs), which are crucial for the pathological analysis of some blood diseases such as malaria. Over the past decades, numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes. Here, we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions. Specifically, we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions, where the strength of the optical nonlinearity increases with osmotic pressure on the cells. This tunable nonlinearity is attributed to optical forces, particularly the forward scattering and gradient forces. Interestingly, in aged blood samples (with lysed cells), a notably different nonlinear behavior is observed due to the presence of free hemoglobin. We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations. Our work on light self-guiding through scattering bio-soft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. Copyright © 2019, The Authors. All rights reserved.

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