Interdependence theory of tissue failure: Bulk and boundary effects

作     者：Suma, Daniel Acun, Aylin Zorlutuna, Pinar Vural, Dervis Can 

作者机构：Department of Bioengineering University of Minnesota Bioengineering Graduate Program University of Notre Dame Department of Aerospace and Mechanical Engineering University of Notre Dame Department of Physics University of Notre Dame United States 

出 版 物：《arXiv》 (arXiv)

年 卷 期：2017年

核心收录：

主　　题：Analytical models 

摘      要：The mortality rate of many complex multicellular organisms increase with age, which suggests that net aging damage is accumulative, despite remodeling processes. But how exactly do little mishaps in the cellular level accumulate and spread to become a systemic catastrophe? To address this question we present experiments with synthetic tissues, an analytical model consistent with experiments, and a number of implications that follow the analytical model. Our theoretical framework describes how shape, curvature and density influences the propagation of failure in a tissue subject to oxidative damage. We propose that aging is an emergent property governed by interaction between cells, and that intercellular processes play a role that are at least as important as intracellular ones. Copyright © 2017, The Authors. All rights reserved.