Neurological manifestations by sex and age group in COVID-19 inhospital patients

作     者：Pereira, Daniella Nunes Bicalho, Maria Aparecida Camargos Jorge, Alzira de Oliveira Gomes, Angélica Gomides dos Reis Schwarzbold, Alexandre Vargas Araújo, Anna Luiza Homan Cimini, Christiane Corrêa Rodrigues Ponce, Daniela Rios, Danyelle Romana Alves Grizende, Genna Maira Santos Manenti, Euler Roberto Fernandes Anschau, Fernando Aranha, Fernando Graça Bartolazzi, Frederico Batista, Joanna d'Arc Lyra Tupinambás, Julia Teixeira Ruschel, Karen Brasil Ferreira, Maria Angélica Pires Paraíso, Pedro Gibson Araújo, Silvia Ferreira Teixeira, Antonio Lucio Marcolino, Milena Soriano 

作者机构：Faculdade de Medicina Universidade Federal de Minas Gerais Brazil Fundação Hospitalar do Estado de Minas Gerais (Fhemig) Germany Hospital Risoleta Tolentino Neves Brazil Hospitais da Rede Mater Dei Brazil Hospital Universitário de Santa Maria/EBSERH Universidade Federal de Santa Maria Brazil Hospital Universitário Ciências Médicas Brazil Hospital Santa Rosália Brazil Hospital das Clínicas da Faculdade de Medicina de Botucatu Brazil Complexo da Saúde São João de Deus Universidade Federal de São João del-Rei Brazil Santa Casa de Misericórdia de Belo Horizonte Brazil Hospital Mãe de Deus Brazil Grupo Hospitalar Conceição Brazilian National Health System Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor Brazil Hospital SOS Cárdio Brazil Hospital Santo Antônio Brazil Universidade Federal Fronteira do Sul Brazil Hospital Metropolitano Odilon Behrens Brazil Hospital Mãe de Deus Hospital Universitário de Canoas Universidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ) Brazil Hospital de Clínicas de Porto Alegre IATS/CnPq Brazil Orizonti- Instituto Oncomed de Saúde e Longevidade Brazil Hospital Semper Brazil Faculdade Santa Casa BH Brazil Department of Internal Medicine Medical School and Telehealth Center University Hospital Universidade Federal de Minas Gerais Brazil Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM) Brazil Institute for Health Technology Assessment (IATS/ CNPq) Brazil Campus Centro Oeste Dona Lindu Universidade Federal de São João del-Rei Brazil Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ) Brazil Hospital Regional do Oeste Brazil Neuropsychiatry Program Department of Psychiatry and Behavioral Sciences UT Health Houston Brazil 

出 版 物：《eNeurologicalSci》 (eNeurologicalSci)

年 卷 期：2022年第28卷

页      面：100419页

基　　金：Instituto de Avaliação de Tecnologias em Saúde Minas Gerais State Agency for Research and Development National Institute of Science and Technology for Health Technology Assessment Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, (147122/2021–0, 310561/2021–3, 465518/2014–1) Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq Fundação de Amparo à Pesquisa do Estado de Minas Gerais, FAPEMIG, (APQ-01154-21) Fundação de Amparo à Pesquisa do Estado de Minas Gerais, FAPEMIG 

主　　题：Age COVID-19 Delirium Neurological manifestations Sex 

摘      要：Introduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p 0.001;OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p 0.001, OR 1.07, 95% CI 1.06–1.07;0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02;0.2% vs. 1.3% p 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures. © 2022 The Authors