Biocompatible Ferrofluid Robot With Photothermal Property for Targeted Tumor Therapy

作     者：Ji, Yiming Bai, Xue Sun, Hongyan Wang, Luyao Xu, Junjie Gan, Chunyuan Dai, Yuguo Hui, Hui Feng, Lin 

作者机构：Beihang Univ Sch Mech Engn & Amp Automat Beijing 100191 Peoples R China Inst Automat CAS Key Lab Mol Imaging State Key Lab Management & Control Complex Syst Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100080 Peoples R China Beihang Univ Beijing Adv Innovat Ctr Biomed Engn Sch Mech Engn & Amp Automat Beijing 100083 Peoples R China 

出 版 物：《IEEE ROBOTICS AND AUTOMATION LETTERS》 (IEEE Robot. Autom.)

年 卷 期：2022年第7卷第4期

页      面：11517-11522页

核心收录：

学科分类：0808[工学-电气工程] 08[工学] 0811[工学-控制科学与工程] 

基　　金：National Key R&D Program of China [2019YFB1309700] Beijing Nova Program of Science and Technology [Z191100001119003] 

主　　题：Soft robot materials and design soft robot applications medical robots and systems 

摘      要：Magnetic-controlled micro-robots have promising applications in disease therapy due to their high targetability and drug utilization. Due to their unique deformable and divisible properties, ferrofluid robots have gained much attention in microchemical reaction chips and micromanipulation. This letter proposes a biocompatible ferrofluid robot and validates its potential to achieve targeted drug delivery and tumor cell killing. This biocompatible ferrofluidic robot contains 10 nm oleic acid-coated ferric tetroxide particles and vegetable oil and has good magnetic responsiveness, deformability, and photothermal properties, and can move in liquid environments such as blood. It can achieve motion with an error of less than 0.4 mm under closed-loop control and obstacle overturning and passage through narrow channels less than twice its diameter. In addition, the biocompatible ferrofluid robot can kill tumor cells in the target area due to the photothermal properties of the magnetic particles, and experimental results show that the tumor cell death rate can reach 95%. These capabilities give the biocompatible ferrofluid robot a significant advantage in getting the target location for cancer treatment through the vascular environment.