Association between serum uric acid-to-creatinine ratio and non-alcoholic fatty liver disease: a cross-sectional study in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol

作     者：Wang, Xiaoyu Han, Yong Liu, Yufei Hu, Haofei 

作者机构：Hechi Peoples Hosp Dept Nephrol Hechi 547000 Guangxi Zhuang Peoples R China Shenzhen Second Peoples Hosp Dept Emergency Shenzhen 518000 Guangdong Peoples R China Shenzhen Univ Affiliated Hosp 1 Dept Emergency Shenzhen 518000 Guangdong Peoples R China Shenzhen Second Peoples Hosp Dept Neurosurg Shenzhen 518000 Guangdong Peoples R China Shenzhen Univ Affiliated Hosp 1 Dept Neurosurg Shenzhen 518000 Guangdong Peoples R China Shenzhen Second Peoples Hosp Dept Nephrol 3002 Sungang Rd Shenzhen 518000 Guangdong Peoples R China Shenzhen Univ Affiliated Hosp 1 Dept Nephrol Shenzhen 518000 Guangdong Peoples R China Shenzhen Univ Hlth Sci Ctr Shenzhen 518000 Guangdong Peoples R China 

出 版 物：《BMC GASTROENTEROLOGY》 (BMC胃肠病学)

年 卷 期：2022年第22卷第1期

页      面：419-419页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Shenzhen Key Medical Discipline Construction Fund [SZXK009] Discipline Construction Ability Enhancement Project of the Shenzhen Municipal Health Commission [SZXJ2017031] 

主　　题：Non-alcoholic fatty liver disease Serum uric acid-to-creatinine ratio Cross-sectional study Non-linear Generalized additive model Binary logistic regression model 

摘      要：Objective Evidence regarding the relationship between serum uric acid-to-creatinine (SUA/Scr) ratio and non-alcoholic fatty liver disease (NAFLD) in Chinese non-obese people is still limited. Therefore, the present study was undertaken to analyze the association between the SUA/Scr ratio and NAFLD. Methods This study was a cross-sectional study that non-selectively and consecutively collected 182,320 non-obese individuals with a normal range of low-density lipoprotein cholesterol in a Chinese hospital from January 2010 to December 2014. A binary logistic regression model was used to evaluate the independent association between the SUA/Scr ratio and NAFLD. A generalized additive model (GAM) and smooth curve fitting (penalized spline method) was conducted to explore the exact shape of the curve between them. A series of sensitivity analyses were used to ensure the robustness of the results. Moreover, subgroup analyses were conducted. In addition, the diagnostic value of the SUA/Scr ratio for NAFLD was evaluated based on the area under the receiver-operating characteristic curve (AUROC). It was stated that the data had been uploaded to the DATADRYAD website. Results The average participants age was 40.96 +/- 14.05 years old, and 90,305 (49.5%) were male. The prevalence of NAFLD was 13.7%, and the mean SUA/Scr was 3.62 +/- 0.92. After adjusting covariates, the results showed that SUA/Scr ratio was positively associated with NAFLD (OR = 1.424, 95%CI: 1.396, 1.454). There was also a non-linear relationship between SUA/Scr ratio and NAFLD in participants with normal kidney function, and the inflection point of the SUA/Scr ratio was 4.425. The effect sizes (OR) on the left and right sides of the inflection point were 1.551 (1.504, 1.599) and 1.234 (1.179, 1.291), respectively. And the sensitive analysis demonstrated the robustness of the results. Subgroup analysis showed a stronger association between SUA/Scr ratio and NAFLD in females and the population with age 50 year