Preparation of hollow spherical covalent organic frameworks via Oswald ripening under ambient conditions for immobilizing enzymes with improved catalytic performance

作     者：Hao Zhao Guanhua Liu Yunting Liu Liya Zhou Li Ma Ying He Xiaobing Zheng Jing Gao Yanjun Jiang Hao Zhao;Guanhua Liu;Yunting Liu;Liya Zhou;Li Ma;Ying He;Xiaobing Zheng;Jing Gao;Yanjun Jiang

作者机构：School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China State Key Laboratory of Biocatalysis and Enzyme EngineeringSchool of Life SciencesHubei UniversityWuhan 430062China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2023年第16卷第1期

页      面：281-289页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.22078081,21908040,21901058,and 22178083) the Natural Science Foundation of Hebei Province(Nos.B2020202021 and B2019202216) Key Research and Development Program of Hebei Province(No.20372802D) Open Project Funding of the State Key Laboratory of Biocatalysis and Enzyme Engineering(No.SKLBEE2020011) the Natural Science Foundation of Tianjin(No.20JCYBJC00530) 

主　　题：hollow spherical structure covalent organic framework Oswald ripening mechanism lipase kinetic resolution 

摘      要：The hollow spherical covalent organic frameworks(COFs)have a wide application prospect thanks to their special ***,the controllable synthesis of uniform and stable hollow COFs is still a *** herein propose a self-templated method for the preparation of hollow COFs through the Ostwald ripening mechanism under ambient conditions,which avoids most disadvantages of the commonly used hard-templating and soft-templating methods.A detailed time-dependent study reveals that the COFs are transformed from initial spheres to hollow spheres because of the inside-out Ostwald ripening *** obtained hollow spherical COFs have high crystallinity,specific surface area(2,036 m^(2)·g^(−1)),stability,and single-batch *** to unique hollow structure,clear through holes,and hydrophobic pore environment of the hollow spherical COFs,the obtained immobilized lipase(BCL@H-COF-OMe)exhibits higher thermostability,polar organic solvent tolerance,and *** BCL@H-COF-OMe also shows higher catalytic performance than the lipase immobilized on non-hollow COF and free lipase in the kinetic resolution of secondary *** study provides a simple approach for the preparation of hollow spherical COFs,and will promote the valuable research of COFs in the field of biocatalysis.