Extracellular vesicles and their non-coding RNA cargos: Emerging players in cardiovascular disease

作     者：Collado, Aida Gan, Lu Tengbom, John Kontidou, Eftychia Pernow, John Zhou, Zhichao 

作者机构：Karolinska Inst Dept Med Solna Div Cardiol Stockholm Sweden Sichuan Univ West China Hosp Dept Emergency Med Lab Emergency Med Chengdu Peoples R China Karolinska Univ Hosp Dept Cardiol Stockholm Sweden 

出 版 物：《JOURNAL OF PHYSIOLOGY-LONDON》 (生理学杂志)

年 卷 期：2023年第601卷第22期

页      面：4989-5009页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071003[理学-生理学] 

基　　金：Swedish Heart and Lung Foundation [20190341, 20200326, 20190266] Karolinska Institutet KID Grant [2021-00275] Swedish Research Council [2020-01372] Stockholm County Council ALF Formas [2020-01372] Funding Source: Formas Swedish Heart-Lung Foundation [20200326, 20190341, 20190266, 20190266] Funding Source: Swedish Heart-Lung Foundation Swedish Research Council [2020-01372] Funding Source: Swedish Research Council 

主　　题：cardiovascular disease extracellular vesicles non-coding RNA therapy 

摘      要：Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, have recently received attention as essential mechanisms for cell-to-cell communication in cardiovascular disease. EVs can be released from different types of cells, including endothelial cells, smooth muscle cells, cardiac cells, fibroblasts, platelets, adipocytes, immune cells and stem cells. Non-coding (nc)RNAs as EV cargos have recently been investigated in the cardiovascular system. Up- or downregulated ncRNAs in EVs have been shown to play a crucial role in various cardiovascular diseases. Communication via EV-derived ncRNAs can occur between cells of the same type and between different types of cells involved in the pathophysiology of cardiovascular disease. In the present review, we highlight the important aspects of diverse cell-derived EVs and their ncRNA cargos as disease mediators and potential therapeutic targets in atherosclerosis, coronary artery disease, ischaemic heart disease and cardiac fibrosis. In addition, we summarize the potential of EV-derived ncRNAs in the treatment of cardiovascular disease. Finally, we discuss the different methods for EV isolation and characterization. A better understanding of the specific role of EVs and their ncRNA cargos in the regulation of cardiovascular (dys)function will be of importance for the development of diagnostic and therapeutic tools for cardiovascular disease.