Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation

作     者：Shuyin Bao Xiuzhi Wang Qianqian Ma Chengxi Wei Jixing Nan Wuliji Ao Shuyin Bao;Xiuzhi Wang;Qianqian Ma;Chengxi Wei;Jixing Nan;Wuliji Ao

作者机构：Institute of Pharmaceutical Chemistry and PharmacologyInner Mongolia Minzu UniversityTongliao 028000China Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular SystemTongliao 028000China Department of Medicines and FoodsTongliao Vocational CollegeTongliao 028000China Jilin Key Laboratory for Traditional Chinese Korean MedicineCollege of PharmacyYanbian UniversityYanji 133002China Research and development centerInner Mongolia Research Institute of Traditional Mongolian Medicine Engineering TechnologyTongliao 028000China Mongolian Medicine R&D National Local Union Engineering Research CenterInner Mongolia Minzu UniversityTongliao 028000China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2022年第14卷第3期

页      面：367-375页

学科分类：1006[医学-中西医结合] 1005[医学-中医学] 100513[医学-民族医学(含：藏医学、蒙医学等)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (Grant numbers 82004070,82160814) the Science and Technology Project of Inner Mongolia (Grant numbers 2020GG0103) the Natural Science Foundation of Inner Mongolia(Grant numbers 2018MS08123) the Mongolian Medicine R&D National and Local Joint Engineering Research Center Open Fund Project (Grant numbers MDK2020001,MDK2021023) Science and Technology Research Project of Higher Education of Inner Mongolia Autonomous Region (Grant numbers NJZY21641) Science and Technology Project of Tongliao (Grant numbers TLKJ2020001) 

主　　题：Mongolian medicine nonalcoholic fatty liver disease type 2 diabetes mellitus Xike Rixijing Disease 

摘      要：Type 2 diabetes mellitus(T2DM)and nonalcoholic fatty liver disease(NAFLD)are the most problematic metabolic diseases in the *** encompasses a spectrum of severity,ranging from simple steatosis to non-alcoholic steatohepatitis(NASH)and fibrosis,increasing the risk of cirrhosis and hepatocellular ***,NAFLD is closely linked to obesity and tightly interrelated with insulin resistance and T2DM.T2DM and NAFLD(T2DM-NAFLD)are called as the Xike Rixijing Disease and Tonglaga Indigestion Disease respectively,in Mongolian *** Rixijing Disease maybe develop into Tonglaga Indigestion *** many Mongolian medicines show efficient treatment of T2DM-NAFLD,such as Agriophyllum squarrosum,Haliyasu(dried powder of camel placenta),Digeda-4(herbs of Lomatogonium carinthiacum,rhizomata of Coptis chinensis,ripe fruits of Gardenia jasminoides,herbs of Dianthus superbus),Guangmingyan Siwei Decoction Powder(Halite,ripe fruits of Terminalia chebula,rhizomata of Zingiber officinale,fruit clusters of Piper longum),Tonglaga-5(ripe fruits of Punica granatum,barks of Cinnamomum cassia,ripe fruits of Amomum kravanh,fruit clusters of Piper longum,fowers of Carthamus tinctorius),Tegexidegeqi(rhizomata of Inula helenium,ripe fruits of Gardenia jasminoides,rhizomata of Platycodon grandiflorum,rhizomata of Coptis chinensis,heartwood of Caesalpinia sappan),Ligan Shiliu Bawei San(ripe fruits of Punica granatum,barks of Cinnamomum cassia,ripe fruits of Amomum kravanh,fruit clusters of Piper longum,fowers of Carthamus tinctorius,ripe fruits of Amomum tsao-ko,rhizomata of Zingiber officinale),*** of Mongolian medicine in treating diseases:by balancing“three essences or rootsand“seven elements,strengthening liver and kidney function,transporting nutrients to enhance physical strength and disease resistance,and combined with drugs for comprehensive conditioning ***,their molecular mechanisms remain *** this review,we prospect