版权所有:内蒙古大学图书馆 技术提供:维普资讯• 智图
内蒙古自治区呼和浩特市赛罕区大学西街235号 邮编: 010021
作者机构:Department of NeurologyZhongshan HospitalFudan UniversityShanghaiChina CAS Center for Excellence in Brain Science and Intelligence TechnologyShanghaiChina Department of The State Key Laboratory of Medical NeurobiologyThe Institutes of Brain Science and the Collaborative Innovation Center for Brain ScienceFudan UniversityShanghaiChina
出 版 物:《Acta Epileptologica》 (癫痫学报(英文))
年 卷 期:2022年第5卷第3期
页 面:156-168页
学科分类:1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金:This work was supported by the Clinical Research Plan of SHDC(SHDC2020CR3066B)
主 题:Epilepsy Circadian rhythm Sleep Mechanisms Chronotherapy
摘 要:Evidence about the interaction between circadian rhythms(CR)and epilepsy has been expanded with the application of advanced detection *** adequate understanding of how circadian system and epilepsy interact with each other could contribute to more accurate seizure prediction as well as rapid development of potential treatment timed to specific phases of *** this review,we present the reciprocal relationship between CR and epileptic activities from aspects of sleep effect,genetic modulation and brain *** has been found that sleep-wake patterns,circadian timing systems and multidien rhythms have essential roles in seizure activities and interictal epileptiform discharge(IED).For instance,specific distribution patterns of seizures and IED have been reported,i.e.,lighter non-rapid eye movement(NREM)sleep stage(stage 2)induces seizures while deeper NREM sleep stage(stage 3)activates ***,the epilepsy type,seizure type and seizure onset zone can significantly affect the rhythms of seizure *** from the common seizure types,several specific epilepsy syndromes also have a close correlation with sleep-wakefulness *** influences the epilepsy rhythm,and conversely,epilepsy alters the sleep rhythm through multiple *** genes accompanied by two feedback loops of regulation have an important role in cortical excitability and seizure occurrence,which may be involved in the *** suprachiasmatic nuclei(SCN)has a rhythm of melatonin and cortisol secretion under the circadian pattern,and then these hormones can feed back into a central oscillator to affect the SCN-dependent rhythms,leading to variable but prominent influence on ***,we discuss the precise predictive algorithms and chronotherapy strategies based on different temporal patterns of seizure occurrence for patients with epilepsy,which may offer a valuable indication for non-invasive closed-loop treatment *** of the