Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network

作     者：Bonifacio, Sonia Lomeli Chalak, Lina F. Van Meurs, Krisa P. Laptook, Abbot R. Shankaran, Seetha 

作者机构：Stanford Univ Dept Pediat Sch Med Div Neonatal & Dev Med Palo Alto CA 94304 USA Univ Texas Southwestern Med Ctr Dallas Div Neonatal Perinatal Med Dallas TX USA Women & Infants Hosp Rhode Isl Dept Pediat Providence RI USA Wayne State Univ Dept Pediat Detroit MI 48202 USA 

出 版 物：《SEMINARS IN PERINATOLOGY》 (围产期学论文集)

年 卷 期：2022年第46卷第7期

页      面：151639-151639页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [U10 HD21364, U10 HD21373, U10 HD21397, U10 HD21385, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27880, U10 HD27904, U10 HD34216, U10 HD36790, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40521, U10 HD40689] National Center for Advancing Translational Sciences (NCATS) [UL1 TR41, UL1 TR42, UL1 TR77, UL1 TR93, UL1 TR442, UL1 TR454, UL1 TR1117, UL1 TR6] Best Pharmaceuticals for Children Act the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [U10 HD53089, U10 HD53109, U10 HD53119, U10 HD53124, U10 HD68270, U10 HD68244, U10 HD68263, U10 HD68278, U10 HD68284] 

主　　题：aEEG Amplitude integrated electroencephalogram ALIC Anterior limb of the internal capsule BGT Basal ganglia/thalamus cEEG Continuous electroencephalogram CI Confidence interval CP Cerebral palsy EEG Electroencephalogram EPO Erythropoietin FSIQ Full scale intelligence quotient GMFCS Gross Motor Function Classification System HEAL High-dose Erythropoietin for Asphyxia and Encephalopathy HIE Hypoxic ischemic encephalopathy HIC High income country ICE Infant Cooling Evaluation trial IQ Intelligence quotient HIE Hypoxic-ischemic encephalopathy LMIC Low-middle income country MDI Mental developmental index MRI Magnetic resonance imaging NCT ClinicalTrials.gov Identifier NEPSY NEuroPSYchological assessment NICHD Eunice Kennedy Shriver National Institute of Child Health and Human Development NRN Neonatal Research Network OC Optimizing Cooling trial PCO 2 Partial pressure of carbon dioxide PPHN Persistent pulmonary hypertension of the newborn PLIC Posterior limb of the internal capsule RCT Randomized controlled trial SA Sedation-analgesia Tes Esophageal temperature TH Therapeutic hypothermia TOBY Total Body Hypothermia trial WeeFIM Functional Independence Measures for Children WM White matter WS Watershed 

摘      要：Therapeutic hypothermia (TH) is now well established as the standard of care treatment for moderate to severe neonatal encephalopathy secondary to perinatal hypoxic ischemic encephalopathy (HIE) in infants 36 weeks gestation in high income countries. The Neonatal Research Network (NRN) contributed greatly to the study of TH as a neuroprotectant with three trials now completed in infants = 36 weeks gestation and the only large randomized-controlled trial of TH in preterm infants now in the follow-up phase. Data from the first NRN TH trial combined with data from other large trials of TH affirm the safety and neuroprotective qualities of TH and highlight the importance of providing TH to all infants who qualify. In this review we will highlight the findings of the three NRN trials of TH in the term infant population and the secondary analyses that continue to inform the care of patients with HIE. (C) 2022 Published by Elsevier Inc.