Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond

作     者：Abd El Fattah, Yasmine K. Abulsoud, Ahmed I. AbdelHamid, Sherihan G. Hamdy, Nadia M. 

作者机构：Heliopolis Univ Fac Pharm Dept Biochem Cairo Egypt Al Azhar Univ Fac Pharm Dept Biochem Boys Branch Nasr City Cairo Egypt Ain Shams Univ Fac Pharm Biochem Dept Cairo Egypt Ain Shams Univ Fac Pharm Abbasiya 11566 Cairo Egypt 

出 版 物：《INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES》 (Int. J. Biol. Macromol.)

年 卷 期：2022年第222卷第PartB期

页      面：1676-1687页

核心收录：

学科分类：0710[理学-生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Epigenetics Non-coding RNA CCDC144NL-AS1 cancer hallmarks microRNA 

摘      要：Long non-coding RNAs (lncRNAs) were, once, viewed as noise for transcription. Recently, many lncRNAs are functionally linked to several human disorders, including cancer. Coiled-Coil Domain Containing 144 N -Ter-minal-Like antisense1 (CCDC144NL-AS1) is a newly discovered cytosolic lncRNA. Aberrant CCDC144NL-AS1 expression was discovered in hepatocellular carcinoma (HCC), ovarian cancer (OC), gastric cancer (GC), non -small cell lung cancer (NSCLC), and osteosarcoma. CCDC144NL-AS1 could be a promising prognostic biolog-ical marker and therapeutic target for cancer. In this review, we will collect and highlight the available infor-mation about CCDC144NL-AS1 role in various cancers. Moreover, we will discuss the diagnostic and prognostic utility of CCDC144NL-AS1 as a new molecular biomarker for several human malignancies, besides its potential therapeutic importance.