Multilayer Scaling of a Biomimetic Microfluidic Oxygenator

作     者：Vedula, Else M. Isenberg, Brett C. Santos, Jose Lai, WeiXuan Lewis, Diana J. Sutherland, David Roberts, Teryn R. Harea, George T. Wells, Christian Teece, Bryan Urban, Joseph Risoleo, Thomas Solt, Derek Leazer, Sahar Chung, Kevin Sukavaneshvar, Sivaprasad Batchinsky, Andriy, I Borenstein, Jeffrey T. 

作者机构：Draper Cambridge MA 02139 USA Geneva Fdn Autonomous Reanimat & Evacuat AREVA Res Program San Antonio TX USA Thrombodyne Inc Salt Lake City UT USA Uniformed Serv Univ Hlth Sci Bethesda MD 20814 USA 

出 版 物：《ASAIO JOURNAL》 (ASAIO J.)

年 卷 期：2022年第68卷第10期

页      面：1312-1319页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：U.S. Army Medical Research Acquisition Activity, Fort Detrick MD U.S. Army, through the Peer-Reviewed Medical Research Program [W81XWH1910518] U.S. Department of Defense (DOD) [W81XWH1910518] Funding Source: U.S. Department of Defense (DOD) 

主　　题：microfluidics oxygenator transfer scaling multilayer 

摘      要：Extracorporeal membrane oxygenation (ECMO) has been advancing rapidly due to a combination of rising rates of acute and chronic lung diseases as well as significant improvements in the safety and efficacy of this therapeutic modality. However, the complexity of the ECMO blood circuit, and challenges with regard to clotting and bleeding, remain as barriers to further expansion of the technology. Recent advances in microfluidic fabrication techniques, devices, and systems present an opportunity to develop new solutions stemming from the ability to precisely maintain critical dimensions such as gas transfer membrane thickness and blood channel geometries, and to control levels of fluid shear within narrow ranges throughout the cartridge. Here, we present a physiologically inspired multilayer microfluidic oxygenator device that mimics physiologic blood flow patterns not only within individual layers but throughout a stacked device. Multiple layers of this microchannel device are integrated with a three-dimensional physiologically inspired distribution manifold that ensures smooth flow throughout the entire stacked device, including the critical entry and exit regions. We then demonstrate blood flows up to 200 ml/min in a multilayer device, with oxygen transfer rates capable of saturating venous blood, the highest of any microfluidic oxygenator, and a maximum blood flow rate of 480 ml/min in an eight-layer device, higher than any yet reported in a microfluidic device. Hemocompatibility and large animal studies utilizing these prototype devices are planned.