Risks of long-term use of proton pump inhibitor on ischemic vascular events: A distributed network analysis of 5 real-world observational Korean databases using a common data model

作     者：Kim, Yerim Seo, Seung In Lee, Kyung Joo Kim, Jinseob Yoo, Jong Jin Seo, Won-Woo Shin, Woon Geon 

作者机构：Hallym Univ Kangdong Sacred Heart Hosp Dept Neurol Coll Med Seoul South Korea Hallym Univ Kangdong Sacred Heart Hosp Dept Internal Med Coll Med Seoul South Korea Hallym Univ Univ Ind Fdn Chunchon South Korea Seoul Natl Univ Sch Publ Hlth Dept Epidemiol Seoul South Korea 

出 版 物：《INTERNATIONAL JOURNAL OF STROKE》 (国际脑卒中杂志)

年 卷 期：2023年第18卷第5期

页      面：590-598页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI19C0481, HC19C0077] Basic Science Research Program through the National Research Foundation of Korea - Ministry of Science and ICT [NRF-276 2022R1F1A1074643] 

主　　题：Common data model H2 receptor antagonist ischemic stroke proton pump inhibitors stroke 

摘      要：Background: Proton pump inhibitors (PPIs) are frequently prescribed drugs. However, it has been suggested that they are associated with an increased risk of ischemic vascular events (IVE) including stroke, although the data are inconsistent. Aims: We investigated the association between PPIs use and IVE in five observational Korean databases using a common data model (CDM). Methods: This study included patient-based retrospective, observational cohort data of subjects aged over 18 years between January 1, 2004, and December 31, 2020, from five medical centers as part of the Observational Medical Outcomes Partnership (OMOP) CDM. Subjects who were included in both cohorts or had a previous history of ischemic stroke were excluded. After propensity matching, 8007 propensity-matched pairs between the PPIs and H-2 receptor antagonist (H(2)RA) users were included in this study. Results: In the 1:1 propensity score matching with 8007 in each group, long-term PPIs use ( 365 days) was not associated with ischemic stroke (odds ratio (OR) = 1.05, 95% confidence interval (CI) 0.71-1.56;I-2 = 57%), ischemic stroke and transient ischemic attack (OR = 1.02, 95% CI 0.71-1.48;I-2 = 53%), and net adverse clinical events (OR = 1.08, 95% CI 0.83-1.40;I-2 = 47%) compared with H2RAs users. Conclusions: Our analysis in a large dataset found no evidence that long-term use of PPIs was associated with an increased risk of ischemic stroke.