The Use of Statin-Class Compounds to Suppress Methanogenesis in Lake Sediment Inoculated Microbial Fuel Cells

作     者：Jayathilake, Chamindu Dilangani, Gayani P. Bandara, Sampath Nazeer, Zumaira Thilini, Nirath Bandara, Wijendra Herath, Ajith C. Kyazze, Godfrey Fernando, Eustace Y. 

作者机构：Department of Biology Faculty of Applied Sciences Rajarata University Mihintale50300 Sri Lanka Faculty of Technology Rajarata University 50300 Sri Lanka Department of Physics Faculty of Science University of Peradeniya Sri Lanka Department of Chemistry Faculty of Applied Sciences Rajarata University 50300 Sri Lanka Faculty of Life Sciences University of Westminster 115 New Cavendish Street LondonW1W 6UW United Kingdom 

出 版 物：《SSRN》 

年 卷 期：2022年

核心收录：

主　　题：Microbial fuel cells 

摘      要：Methanogenesis conducted by archaea acts as a competing metabolic pathway that diverts available carbon and electrons away from exo-electrogenic metabolism in mixed culture inoculated microbial fuel cells (MFCs). Statin-class compounds are known to selectively inhibit eukaryotic and archaeal versions of HMG Co-A reductase (class-I) enzyme. This study demonstrated that the two statin compounds Simvastatin and Atorvastatin were effective in suppressing methanogenesis in MFCs. Power densities increased 2 fold compared to control (to 63 ± 1.8 mW/m 2 ) and 2.5 fold (to 69.5 ± 1.8 mW/m 2 ) with Simvastatin and Atorvastatin addition respectively. There was an almost complete suppression of CH 4 production when statins were added. Quantitative FISH (qFISH) analysis showed that methanogens Methanosarcina, Metanobacteria and Methanomicrobiales together with all archaea were almost completely suppressed when statins were supplemented into MFC anodes. This study demonstrated that the statins addition can be used to boost power densities in MFCs. © 2022, The Authors. All rights reserved.