Interplays of liver fibrosis-associated microRNAs:Molecular mechanisms and implications in diagnosis and therapy

作     者：Hong Li Tingli Liu Yongchun Yang William C.Cho Robin J.Flynn Majid Fasihi Harandi Houhui Song Xuenong Luo Yadong Zheng Hong Li;Tingli Liu;Yongchun Yang;William C.Cho;Robin J.Flynn;Majid Fasihi Harandi;Houhui Song;Xuenong Luo;Yadong Zheng

作者机构：State Key Laboratory of Veterinary Etiological BiologyKey Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhouGansu 730046China Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang ProvinceZhejiang Provincial Engineering Laboratory for Animal Health Inspection&Internet TechnologyZhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health ManagementChina-Australia Joint Laboratory for Animal Health Big Data AnalyticsCollege of Animal Science and Technology&College of Veterinary Medicine of Zhejiang A&F UniversityHangzhouZhejiang 311300China Department of Clinical OncologyQueen Elizabeth HospitalHong Kong SAR 999077China Department of Infection BiologyInstitute of Infection and Global HealthUniversity of LiverpoolLiverpool L35RFUK Graduate Studies OfficeDepartment of ResearchInnovation and Graduate StudiesWaterford Institute of TechnologyX91 K0EKIreland Research Center for Hydatid Disease in IranKerman University of Medical SciencesKerman ***Iran 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第4期

页      面：1457-1469页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.32072889,U1703104) Key R&D Program of Zhejiang Province(China)(No.2019C02052) Scientific Research and Development Talent Fund of Zhejiang Agriculture and Forestry University,China(No.2021LFR038) 

主　　题：Diagnosis Hepatic stellate cell Liver fibrosis miRNA Therapy 

摘      要：microRNAs(miRNAs)are a class of non-coding functional small RNA composed of 21e23 nucleotides,having multiple associations with liver ***-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis *** former is capable of activating hepatic stellate cells(HSCs)by modulating pro-fibrotic signaling pathways,mainly including TGF-b/SMAD,WNT/b-catenin,and Hedgehog;the latter is responsible for maintenance of the quiescent phenotype of normal HSCs,phenotypic reversion of activated HSCs(aHSCs),inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene ***,several miRNAs are involved in regulation of liver fibrosis via alternative mechanisms,such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of ***,understanding the role of these miRNAs may provide new avenues for the development of novel interventions against hepatic fibrosis.