Preparation of multicore millimeter-sized spherical alginate capsules to specifically and sustainedly release fish oil

作     者：Lina Tao Panpan Wang Ting Zhang Mengzhen Ding Lijie Liu Ningping Tao Xichang Wang Jian Zhong Lina Tao;Panpan Wang;Ting Zhang;Mengzhen Ding;Lijie Liu;Ningping Tao;Xichang Wang;Jian Zhong

作者机构：National R&D Branch Center for Freshwater Aquatic Products Processing Technology(Shanghai)Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product ProcessingMinistry of Agriculture and Rural Affairs of the People's Republic of ChinaShanghai Engineering Research Center of Aquatic-Product Processing and PreservationCollege of Food Science&TechnologyShanghai Ocean UniversityShanghai 201306China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第2期

页      面：397-406页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：supported by research grants from the National Key R&D Program(2019YFD0902003) 

主　　题：Ionotropic gelation Millimeter-sized spherical capsule Monoaxial dispersion electrospraying Multicore Specific and sustained release 

摘      要：Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug *** this work,we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish *** spherical capsules had diameters from 2.05 mm to 0.35 mm with the increased applied *** capsules consisted of uniform(at applied voltages of≤10 k V)or nonuniform(at applied voltages of10 k V)*** obtained capsules had reasonable loading ratios(9.7%-6.3%)due to the multicore *** addition,the obtained capsules had specific and sustained release behaviors of fish oil into the small intestinal phase of in vitro gastrointestinal tract and small intestinal tract *** simple monoaxial dispersion electrospraying-ionotropic gelatin technique does not involve complicated preparation formulations and polymer modification,which makes the technique has a potential application prospect for the fish oil preparations and the encapsulation of functional active substances in the field of food and drug industries.