Oral Intervention of Narirutin Ameliorates the Allergic Response of Ovalbumin Allergy

作     者：Shi, Xiaolei Zhao, Lina Niu, Liyan Yan, Yixuan Chen, Qiushi Jin, Yongri Li, Xuwen 

作者机构：Jilin Univ Coll Food Sci & Engn Changchun 130012 Peoples R China Jilin Univ Coll Chem Changchun 130012 Peoples R China 

出 版 物：《JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY》 (J. Agric. Food Chem.)

年 卷 期：2022年第70卷第41期

页      面：13313-13326页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 09[农学] 0703[理学-化学] 0901[农学-作物学] 

基　　金：National Natural Science Foundation of China Fundamental Research Funds for the Central Universities 31201295 

主　　题：oral tolerance narirutin food allergy OVA intervention network pharmacology 

摘      要：A new intervention was investigated for the induction of oral tolerance (OT) of OVA using narirutin by in vivo and in vitro experiments combined with network pharmacology and structural analysis of molecular docking. Narirutin (and its metabolism naringenin) has effects on OT by affecting B cell function, DCs, and T cell response by prediction. It was verified that narirutin could affect B cell function of secreting antibodies, thereby reducing the ability of DCs to absorb antigens by affecting GATA3, CCR7, STAT5, and MHCII expression and regulating T cell response by suppressing Th2 and improving Treg cells in vivo. Molecular docking showed that steric hindrance effects may be the reason for weaker binding energy with targets of narirutin. However, this does not mean that it has no bioactivity, for it can inhibit mast cell degranulation. This finding is interesting because it offers the possibility of using natural compounds to promote oral tolerance.