Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

作     者：Xiaowei MAO Kexin CHEN Yanlong ZHAO Chunrong Xiong Jing LUO Yuguang WANG Bo WANG Hongyu ZHANG Xiaowei MAO;Kexin CHEN;Yanlong ZHAO;Chunrong Xiong;Jing LUO;Yuguang WANG;Bo WANG;Hongyu ZHANG

作者机构：School of Chemical Engineering and TechnologyHainan UniversityHaikou 570228China State Key Laboratory of TribologyDepartment of Mechanical EngineeringTsinghua UniversityBeijing 100084China Peking University School of Nursing&National Engineering Laboratory for Digital and Material Technology of StomatologyBeijing 100191China Beijing Research Institute of Automation for Machinery Industry Co.Ltd.Beijing 100120China Center of Digital DentistryPeking University School and Hospital of Stomatology&NHC Research Center of Engineering and Technology for Computerized DentistryBeijing 100081China College of Chemical and Biological EngineeringShandong University of Science and TechnologyQingdao 266590China 

出 版 物：《Friction》 (摩擦（英文版）)

年 卷 期：2023年第11卷第7期

页      面：1194-1211页

核心收录：

学科分类：081702[工学-化学工艺] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 

基　　金：financially supported by the National Natural Science Foundation of China(52022043 and 21868011) Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program(20191080593) Precision Medicine Foundation,Tsinghua University,China(10001020107) the National Key R&D Program of China(2017YFC1103800) Research Fund of State Key Laboratory of Tribology,Tsinghua University,China(SKLT2022C18) 

主　　题：surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication osteoarthritis 

摘      要：Osteoarthritis is associated with the significantly increased friction of the joint,which results in progressive and irreversible damage to the articular cartilage.A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage *** the present study,bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages,a biomimetic self-adhesive dopamine methacrylamide-poly(2-methacryloyloxyethyl phosphorylcholine)(DMA-MPC)copolymer was designed and synthesized via free radical *** copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles(bMSNs)by the dip-coating method to prepare the dual-functional nanoparticles(bMSNs@DMA-MPC),which were evaluated using a series of surface characterizations including the transmission electron microscope(TEM),Fourier transform infrared(FTIR)spectrum,thermogravimetric analysis(TGA),X-ray photoelectron spectroscopy(XPS),*** tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug,i.e.,diclofenac sodium(DS).In addition,the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 ***,the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β(IL-1β)and interleukin-6(IL-6).In summary,the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.