A Biomimetic Nanoplatform for Precise Reprogramming of Tumor-Associated Macrophages and NIR-II Mediated Antitumor Immune Activation

作     者：Ding, Yuan Qian, Xiaohui Lin, Fenghao Gao, Bingqiang Wang, Weili Yang, Huang Du, Yang Wang, Weilin 

作者机构：Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Zhejiang Hangzhou310009 China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Zhejiang Hangzhou310009 China Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province Zhejiang Hangzhou310009 China National Innovation Center for Fundamental Research on Cancer Medicine Zhejiang Hangzhou310009 China Cancer Center Zhejiang University Zhejiang Hangzhou310058 China ZJU-Pujian Research & Development Center of Medical Artificial Intelligence for Hepatobiliary and Pancreatic Disease Zhejiang Hangzhou310058 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Zhejiang Hangzhou310027 China Department of Hepatobiliary and Pancreatic Surgery 

出 版 物：《SSRN》 

年 卷 期：2022年

核心收录：

主　　题：Cell death 

摘      要：The therapeutic effects of photothermal therapy (PTT) are dependent on the photothermal conversion efficiency of photothermal agents (PTAs) in tumors and the subsequent activation of the antitumor immune system. However, the insufficient tumor accumulation of current PTAs and the inevitable recruitment of tumor-associated macrophages (TAMs) could further compromise the antitumor activities of PTT. To address these issues, a biomimetic photothermal nanoplatform Au@Fe-PM is developed for the targeted remodeling of TAMs, which promotes the antitumor immunity of PTT. Au nanorods with second near-infrared (NIR-II) absorptions are fabricated to serve as PTAs to induce immunogenic cell death in tumor cells. The ferric hydroxide shell coated on Au nanorods can release iron ions to repolarize M2-like TAMs into the tumoricidal M1 phenotype via P38 and STAT1-mediated signaling pathways. Moreover, the surface decoration of platelet membranes endows biomimetic nanoplatform with excellent tumor targeting ability for precise tumor ablation and TAM regulation. Consequently, Au@Fe-PM under NIR-II laser irradiation exhibits significantly higher inhibitory effects in a poor immunogenic 4T1 tumor-bearing mouse model with a 50% complete remission rate compared to conventional PTT (0%). By simultaneously reversing the immunosuppressive tumor microenvironment, this biomimetic nanoplatform offers a promising strategy for enhancing the antitumor efficacy of PTT. © 2022, The Authors. All rights reserved.