The clinical significance of circulating glucose-regulated protein 78, Caspase-3, and C/EBP homologous protein levels in patients with heart failure

作     者：Zhao, Xuecheng Zhang, Da-Qi Song, Rongjing Wang, Rong Zhang, Guoqiang 

作者机构：China Japan Friendship Hosp Dept Emergency Med Beijing Peoples R China Hainan Med Univ Dept Neurol Affiliated Hosp 1 Haikou Peoples R China Peking Univ Peoples Hosp Dept Pharm Beijing Peoples R China Hainan Univ Sch Pharmaceut Sci Haikou Peoples R China Hainan Med Univ Dept Neurol Affiliated Hosp 1 Longhua Rd Haikou 570102 Hainan Peoples R China China Japan Friendship Hosp Dept Emergency Med 2 Yinghua Dongjie Beijing 100029 Peoples R China 

出 版 物：《HELIYON》 (Heliyon)

年 卷 期：2023年第9卷第2期

页      面：e13436页

核心收录：

基　　金：National Natural Science Foundation of China Hainan Province Clinical Medical Center 

主　　题：Glucose-regulated protein 78 Caspase-3 C EBP homologous Protein Heart failure 

摘      要：Background and aims: The destruction of endoplasmic reticulum (ER) homeostasis leads to heart failure (HF), which further aggravates ER stress. Limited data are available on the levels of ER stress markers in HF patients in clinical practice. This study aimed to determine the clinical significance of the ER stress markers, glucose-regulated protein 78 (GRP78), Caspase-3, and C/ EBP homologous protein (CHOP), in predicting HF and its severity. Materials and methods: A total of 62 patients with HF and 44 healthy controls were enrolled in the study, and all participants were followed-up for 2 years. Results: Serum GRP78, Caspase-3, and CHOP levels were significantly higher in patients with HF than those in healthy controls. The level of GRP78 increased with the severity of HF. GRP78 levels were negatively correlated with left ventricular ejection fraction, and positively correlated with N-terminal B-type natriuretic peptide, D-dimer, and lactic acid. Serum GRP78 and Caspase-3 levels showed moderate predictive values for HF patients. Conclusion: ER stress markers, GRP78 and Caspase-3, had a certain predictive value in HF and can be used as serum biomarkers for the diagnosis of HF. Additionally, GRP78 showed a certain predictive value in HF severity.