Novel antioxidant peptide from broken rice resist H_(2)O_(2)-induced premature senescence in 2BS cells via PI3K/Akt and JNK/Bax signaling pathway

作     者：Li-kun Ren Yang Yang Jing Fan Chun-min Ma Xin Bian Dang-feng Wang Yue Xu Bao-xiang Liu Na Zhang 

作者机构：Key Laboratory of Food Science and Engineering of Heilongjiang ProvinceCollege of Food EngineeringHarbin University of CommerceHarbinHeilongjiang150028China College of Food Science and TechnologyJiangnan UniversityWuxiJiangsu214122China College of Food Science and TechnologyBohai UniversityNational&Local Joint Engineering Research Center of StorageProcessing and Safety Control Technology for Fresh Agricultural and Aquatic ProductsJinzhouLiaoning121013China 

出 版 物：《Food Bioscience》 (食品生物科学（英文）)

年 卷 期：2023年第52卷第2期

页      面：345-355页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：We appreciate the financial support from the Major Science and technology Program of Heilongjiang(2020ZX08B02) National Natural Science Foundation of China(32072258) the National Key Research and Development Program of China(2021YFD2100902-3),Central financial support for the development of local colleges and Universities 

主　　题：Peptide Human embryonic lung diploid fibroblast Anti-aging PI3K/Akt JNK/Bax 

摘      要：SGDWSDIGGR(S-10-R)is a kind of antioxidant peptide derived from broken *** the present study,the effects of S-10-R against H_(2)O_(2)-induced cell damage and premature senescence in 2BS cells were *** results indicated that S-10-R could improve cell viability and mitochondrial membrane potential at least 1.06 and 1.12 folds compared with senescence ***,S-10-R inhibitedβ-galactosidase,and DNA damage alleviates the effect on 2BS senescence cells due to scavenging *** apoptosis rate can be reduced by 80.58%.Furthermore,S-10-R could inhibit PI3K and Akt phosphorylation,downregulate Bax and caspases-3 expression,and inhibit premature senescence through activating PI3K/Akt related intrinsic apoptotic signaling pathways and suppressing JNK/Bcl-2 related mitochondria-dependent *** present study confirmed the feasibility of antioxidants as anti-aging drugs,as well as provided a substantial basis for future application of S-10-R as a functional ingredient against oxidative stress-induced premature aging.