A Transparent Ultrasound Array for Real-Time Optical,Ultrasound,and Photoacoustic Imaging

作     者：Haoyang Chen Sumit Agrawal Mohamed Osman Josiah Minotto Shubham Mirg Jinyun Liu Ajay Dangi Quyen Tran Thomas Jackson Sri-Rajasekhar Kothapalli 

作者机构：Department of Biomedical EngineeringThe Pennsylvania State UniversityUniversity ParkPA 16802USA School of Electrical Engineering and Computer ScienceThe Pennsylvania State UniversityUniversity ParkPA 16802USA Penn State Cancer InstituteThe Pennsylvania State UniversityHersheyPA 17033USA Graduate Program in AcousticsThe Pennsylvania State UniversityUniversity ParkPA 16802USA 

出 版 物：《Biomedical Engineering Frontiers》 (生物医学工程前沿（英文）)

年 卷 期：2022年第3卷第1期

页      面：284-297页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 0836[工学-生物工程] 10[医学] 

基　　金：funded by the Penn State Cancer Institute—Highmark Seed Grant (SRK) College of Engineering Multidisciplinary Grant,and Grace Woodward Grant (SRK) 

主　　题：Ultrasound specificity transparent 

摘      要：Objective and Impact *** imaging of ultrasound and optical contrasts can help map structural,functional,and molecular biomarkers inside living subjects with high spatial *** is a need to develop a platform to facilitate this multimodal imaging capability to improve diagnostic sensitivity and ***,combining ultrasound,photoacoustic,and optical imaging modalities is challenging because conventional ultrasound transducer arrays are optically *** a result,complex geometries are used to coalign both optical and ultrasound waves in the same field of *** elegant solution is to make the ultrasound transducer transparent to ***,we demonstrate a novel transparent ultrasound transducer(TUT)linear array fabricated using a transparent lithium niobate piezoelectric material for real-time multimodal *** TUT-array consists of 64 elements and centered at~6 MHz *** demonstrate a quad-mode ultrasound,Doppler ultrasound,photoacoustic,and fluorescence imaging in real-time using the TUT-array directly coupled to the tissue mimicking *** TUT-array successfully showed a multimodal imaging capability and has potential applications in diagnosing cancer,neurological,and vascular diseases,including image-guided endoscopy and wearable imaging.