MDB-15. CLINICAL CHARACTERISTICS AND OUTCOME OF CHILDHOOD LI-FRAUMENI SYNDROME MEDULLOBLASTOMA PATIENTS

作     者：Anna Kolodziejczak Lea Guerrini-Rousseau Julien Masliah Planchon Martin Mynarek Martin Sill Robert Autry Eric Zhao Steffen Hirsch Christelle Dufour Olivier Ayrault Sebastian Waszak Vijay Ramaswamy Virve Pentikainen Steven Clifford Ed Schwalbe Luca Massimi Matija Snuderl Matthias Karajannis Christine White Shelagh Redmond Loizou Loizos Marcus Jakob Irene Schmid Julia Hauer Claudia Blattmann Maria Filippidou Christian Sutter Torsten Pietsch Stephan Frank Denis Schewe David Malkin Astrid Sehested Tai-Tong Wong Fernando Carceller Sabine Mueller Michael Taylor Uri Tabori Eric Bouffet Marcel Kool Felix Sahm Christian Kratz Dominik Sturm David Jones Stefan Rutkowski Olaf Witt Gaëlle Bougeard Kristian Pajtler Stefan Pfister Franck Bourdeaut Till Milde 

作者机构：Hopp Children’s Cancer Center (KiTZ) Heidelberg Germany Department of Children and Adolescents Oncology Gustave Roussy Université Paris-Saclay Villejuif France Somatic Genetics Unit Department of Diagnostic and Theranostic Medicine Institut Curie Paris-Science Lettres University Paris France Pediatric Hematology and Oncology University Medical Center Hamburg-Eppendorf Hamburg Germany Institute of Human Genetics University Hospital Heidelberg Heidelberg Germany Institut Curie PSL Research University CNRS UMR INSERM Orsay France Centre for Molecular Medicine Norway (NCMM) Nordic EMBL Partnership University of Oslo and Oslo University Hospital Oslo Norway Division of Hematology and Oncology Hospital for Sick Children Toronto Canada Division of Hematology-Oncology and Stem Cell Transplantation Children’s Hospital Helsinki University Hospital Helsinki Finland Wolfson Childhood Cancer Research Centre Newcastle University Centre for Cancer Newcastle United Kingdom Pediatric Neurosurgery Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University Medical School Rome Italy Department of Pathology New York University Langone Health New York USA Department of Pediatrics Memorial Sloan Kettering Cancer Center New York USA Hudson Institute of Medical Research Clayton Australia Childhood Cancer Registry Institute of Social and Preventive Medicine University of Bern Bern Switzerland Pediatric Oncology/Hematology/Immunology at the Medical School of the University of Nicosia Nicosia Cyprus Department of Paediatric Haematology Oncology and Stem-Cell Transplantation University Hospital Regensburg Regensburg Germany Paediatric Haematology and Oncology Dr. von Hauner Children’s Hospital Ludwig Maximilians University Munich Munich Germany Department of Pediatrics Technical University Munich Munich Germany Paediatric Haematology Oncology and Immunology Olgahospital Stuttgart Germany Division of Pediatric Hematology-Oncology First Department of Pediatrics National and Kapodistrian University of Athens "Aghia Sophia" Children’s Hospital Athens Greece Institute of Neuropathology DGNN Brain Tumor Reference Center University of Bonn Medical Center Bonn Germany Division of Neuropathology Institute of Pathology Basel University Hospital Basel Switzerland Department of Pediatrics Otto-von-Guericke University Magdeburg Magdeburg Germany Division of Hematology/Oncology Department of Pediatrics The Hospital for Sick Children University of Toronto Toronto Canada Department of Paediatrics and Adolescent Medicine Juliane Marie Centre Copenhagen University Hospital Copenhagen Denmark Division of Pediatric Neurosurgery Department of Neurosurgery Taipei Medical University Hospital Taipei Medical University Taipei Taiwan Paediatric and Adolescent Oncology Drug Development Team Children and Young People’s Unit The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research Sutton United Kingdom Department of Neurology Neurosurgery and Pediatrics University of California San Francisco San Francisco USA Division of Neurosurgery Program in Developmental and Stem Cell Biology Arthur and Sonia Labatt Brain Tumour Research Centre Hospital for Sick Children Toronto Canada Department of Neuropathology Institute of Pathology Heidelberg University Hospital Heidelberg Germany Pediatric Hematology and Oncology Hannover Medical School Hannover Germany CHU Rouen Department of Genetics Rouen France SIREDO Pediatric Oncology Center Institut Curie Paris-Science Lettres University Paris France 

出 版 物：《Neuro-Oncology》 

年 卷 期：2023年第25卷第SUPPLEMENT_1期

页      面：i64–i65页

摘      要：Patients with Li-Fraumeni syndrome (LFS) who develop medulloblastoma (MB) have a very poor prognosis. The development of novel therapeutic strategies is challenged by the lack of clinical data for this patient group. We here present clinical and molecular data on a retrospective cohort of pediatric patients with LFS-associated MB.