Construction of Antimicrobial Peptides/Alginate Multilayers Modified Membrane: Antibiofouling Performance and Mechanisms

作     者：Chen, Yanrui Zhang, Xingran Li, Fang Ma, Jinxing Wang, Zhiwei 

作者机构：College of Environmental Science and Engineering Textile pollution controlling Engineering Centre of Ministry of Ecology and Environment Donghua University Shanghai201620 China Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education School of Ecology Environment and Resources Guangdong University of Technology Guangzhou510006 China State Key Laboratory of Pollution Control and Resource Reuse Shanghai Institute of Pollution Control and Ecological Security School of Environmental Science and Engineering Tongji University Shanghai200092 China 

出 版 物：《SSRN》 

年 卷 期：2023年

核心收录：

主　　题：Peptides 

摘      要：Biofouling remains to be one of major obstacles for membrane-based technology in water and wastewater treatment, calling for the development of antibiofouling membranes. For the traditional release-killing strategy, uncontrollable release of biocides and thus a short lifetime as well as the potentially environmental risk are thorny issues for the modified membranes. Herein, hydrophilic hydrogel multilayers with controllable thickness at nanometer scale on a poly(vinylidene fluoride) (PVDF) microfiltration membrane were constructed via layer-by-layer (LbL) self-assembly of non-drug-resistant antimicrobial peptides (AMPs) and alginate. The AMPs/alginate multilayers modified membranes exhibited enhanced hydrophilicity, well-controlled pore size distribution and prominent antimicrobial ability against Escherichia coli and Staphylococcus aureus. The strong interaction of AMPs and alginate imparted by the gel network enabled the slow release rate of AMPs in water phase (i.e., 1.79 ± 0.07 μg/cm2 d of initial release rate and 0.55 ± 0.03 μg/cm2 d of steady release rate). Long-term antibiofouling tests showed that the AMPs/alginate modified membranes with ten multilayers (MSA10) exhibited a significantly reduced transmembrane pressure increase rate of 0.81 ± 0.01 kPa/d which was much lower than that of the control membranes (1.80 ± 0.20 kPa/d). Furthermore, the AMPs/alginate multilayers modified membranes revealed high stability suffering from long-term operation and chemical cleaning cycles. The novel AMP/alginate-incorporated modifying method provides a new dimension to enhance antibiofouling performance of membranes for water and wastewater treatment. © 2023, The Authors. All rights reserved.