Scale-up Efficient Synthesis of α-Poly(L-lysine)

作     者：Wenxiu Lv Maosheng Li Youhua Tao Wenxiu Lv;Maosheng Li;Youhua Tao

作者机构：Key Laboratory of Polymer EcomaterialsChangchun Institute of Applied ChemistryChinese Academy of SciencesRenmin Street 5625ChangchunJilin130022 China School of Applied Chemistry and EngineeringUniversity of Science and Technology of ChinaHefeiAnhui230026 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2023年第41卷第19期

页      面：2488-2492页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(91856113 and U21A2089) the National Key Research and Development Program of China(2022YFE0130500) 

主　　题：Scale-up _(L)-Cbz-LysNCA α-Poly(_(L)-lysine) Easy operation 

摘      要：α-Poly(_(L)-lysine)(α-PLL)is a water-soluble cationic biopolymer containing the monomeric unitα-_(L)-lysine,which not only possesses excellent intrinsic properties but also can be modified via facile reactions between the side amine groups and many other functional ***-opening polymerization(ROP)is the most prevalently used technique for the synthesis of PL_(L)-based polypeptides,which involves initial conversion of theε-primary amine-protectedα-_(L)-lysine to the _(L)-lysine NCA ***,obtaining N-carboxyanhydrides(NCAs)in high purity has been a formidable challenge for over 50 years,let alone the large-scale ***,we show an unprecedented scale-up synthesis of _(L)-Cbz-LysNCA monomer and its polymers,generating linearα-poly(_(L)-lysine)with molecular weight(MW)up to 13.4 *** easy operated scale-up strategy will lay the foundations for the industrial preparation of _(L)-Cbz-LysNCA and its polymers,and further extend the realm of existing applications,offering a paradigm for scale-up synthesis of other polypeptides.