Fabrication of Highly Aligned Mwcnts Loaded Ngcs for Peripheral Nerve Regeneration Via a Novel One-Step Modified Electrohydrodynamic Printing Method

作     者：Sun, Renyuan Lang, Yuna Wang, Baolin Zhao, Mingkang Li, Chao Liu, Shiheng Zhang, Longfei Chang, Ming-Wei 

作者机构：State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology Tianjin300401 China Tianjin Key Laboratory of Bio-electromagnetic and Neural engineering Hebei University of Technology Tianjin300132 China Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering School of Health Sciences and Biomedical Engineering Hebei University of Technology Tianjin300132 China Nanotechnology and Integrated Bioengineering Centre Jordanstown Campus University of Ulster NewtownabbeyBT37 0QB United Kingdom 

出 版 物：《SSRN》 

年 卷 期：2023年

核心收录：

主　　题：Fibers 

摘      要：The directional growth of Schwann cell can promote the repair of peripheral nerve injury (PNI) and aligned fibers have been proved to promote the directional growth of Schwann cell. However, the preparation of nerve guidance conduits (NGCs) composed of aligned fibers is still a challenge. The aim of this study was to develop a highly aligned NGCs composed of coaxial fibers via a novel one-step modified electrohydrodynamic (EHD) printing method. Multi-walled carbon nanotubes (MWCNTs) were incorporated into the polycaprolactone (PCL) as the outer layer of coaxial fibers, and polyethylene oxide (PEO) was as the core of the fibers. In this study, the effects of the concentration of MWCNTs and the coaxial structure on the performance of the NGCs were evaluated systematically. The results showed that the aligned MWCNTs loaded NGCs composed of coaxial fibers had excellent performance in nerve regeneration and functional recovery while providing suitable mechanical support for nerve regrowth when the loading concentration of MWCNTs was 1%. Therefore, the aligned MWCNTs loaded NGCs composed of coaxial fibers offers essential insights into the preparation of traditional NGCs and highlighted its potential in clinical application. © 2023, The Authors. All rights reserved.