BNIP3 as a new tool to promote healthy brain aging

作     者：Neikirk, Kit Marshall, Andrea G. Santisteban, Monica M. Hinton Jr, Antentor 

作者机构：Vanderbilt Univ Dept Mol Physiol & Biophys 750 Robinson Res Bldg2200 Pierce Ave Nashville TN 37232 USA Vanderbilt Univ Med Ctr Dept Med Nashville TN USA 

出 版 物：《AGING CELL》 (老化细胞)

年 卷 期：2024年第23卷第2期

页      面：e14042-e14042页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 07[理学] 

基　　金：Vanderbilt Diabetes Research and Training Center  Vanderbilt University Medical Center 

主　　题：age-related pathology aging BNIP3 mitochondria neuronal 

摘      要：The article Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila reveals BCL2-interacting protein 3 as a therapeutic target to counteract brain aging and prolong overall organismal health with age. In this spotlight, we consider the roles of BNIP3, a mitochondrial outer membrane protein, in the adult nervous system, including its induction of mitophagy and prevention of dysfunctional mitochondria in the aged brain. Implications for other tissue types to reduce the burden of aging are further considered.