Effect of pharmacological interventions for the treatment of people with post-COVID-19 condition: A rapid review

作     者：K M Saif-Ur-Rahman Kavita Kothari Corinna Sadlier Frank Moriarty Ani Movsisyan Sean Whelan Petek E Taneri Matthew Blair Gordon Guyatt Declan Devane 

作者机构：Evidence Synthesis Ireland and Cochrane Ireland University of Galway Galway Ireland. School of Nursing and Midwifery University of Galway Galway Ireland. Consultant to Library & Digital Information Networks World Health Organization Kobe Japan. Department of Infectious Diseases Cork University Hospital Cork Ireland. Department of Medicine University College Cork Cork Ireland. School of Pharmacy and Biomolecular Sciences Royal College of Surgeons in Ireland Dublin Ireland. Consultant to Methods and Standards Team World Health Organization Geneva Switzerland. Department of Clinical Microbiology Galway University Hospital Galway Ireland. HRB-Trials Methodology Research Network University of Galway Galway Ireland. Department of Health Research Methods Evidence and Impact McMaster University Ontario Canada. 

出 版 物：《Cochrane evidence synthesis and methods》 

年 卷 期：2023年第1卷第1期

页      面：e12001页

主　　题：PCC pharmacological interventions post‐COVID‐19 condition 

摘      要：Objective:Little is known about the treatment of post-coronavirus disease 2019 (COVID-19) condition (PCC). This article examines the effectiveness of pharmacological interventions for treating people with PCC. Methods:We searched Medline, EMBASE, ClinicalTrials. gov, and the International Clinical Trials Registry Platform. Two independent review authors screened citations, extracted data, and assessed the quality of the included studies. Due to heterogeneity in participants, interventions, and outcomes, we synthesized data narratively. We assessed the certainty of evidence using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation). Participants:People with PCC. Interventions:Pharmacological interventions include corticosteroids, ivabradine, and inhaled hydrogen. Outcome Measures:Olfactory function, sinus tachycardia, respiratory function. Results:We identified 5 completed studies and 41 ongoing studies. Oral corticosteroids and olfactory training had higher olfactory scores after 10 weeks (MD: 5.60, 95% confidence interval [CI]: 1.41 to 9.79). Patients allocated oral corticosteroid, and nasal irrigation demonstrated improved recovery of olfactory function compared with the control group at 40 days (median 60, interquartile range [IQR]: 40 vs. median 30, IQR: 25, = 0.024). Patients allocated to topical corticosteroid nasal spray and olfactory training had improved recovery of olfactory function after 2 weeks (median 7, IQR: 5-10 vs. median 5, IQR: 2-8, = 0.08). Participants allocated to ivabradine had a greater mean reduction in heart rate compared with participants randomized to carvedilol (MD: -4.24, 95% CI: -10.09 to 1.61). Participants allocated to inhaled hydrogen therapy had an improved vital capacity (MD: 0.20, 95% CI: 0.07 to 0.33), forced expiratory volume (MD: 0.19, 95% CI: 0.04 to 0.34), 6-minute walk test (MD: 55.0, 95% CI: 36.04 to 73.96). Conclusions:The evidence is of low to very low certainty about the effect of all pharmacolo