Polyphenol-based antibacterial and antioxidative nanoparticles for improved peritonitis therapy

作     者：Jinhong Dong Tianyou Wang Haotian Li Jianhua Zhang Hengjie Zhang Weijie Liu Xinru You Zhipeng Gu Yiwen Li Xianchun Chen Qiang Fu Jinhong Dong;Tianyou Wang;Haotian Li;Jianhua Zhang;Hengjie Zhang;Weijie Liu;Xinru You;Zhipeng Gu;Yiwen Li;Xianchun Chen;Qiang Fu

作者机构：College of Polymer Science and EngineeringState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Center for Nanomedicine and Department of AnesthesiologyBrigham and Women's HospitalHarvard Medical SchoolBostonMA 02215USA 

出 版 物：《Collagen and Leather》 (胶原与皮革(英文))

年 卷 期：2024年第6卷第3期

页      面：80-92页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the project of National Key R&D Program of China(2022YFB3804500) 

主　　题：Biomass materials Natural polyphenols Antibiotics Antioxidative Peritonitis 

摘      要：The development of advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications is highly desirable. In the present investigation, biomass-based nanoparticles(NPs) were assembled through the Mannich reaction between the plant polyphenols and the broad-spectrum antibiotic tigecycline(TG). The fabricated NPs with uniform size demonstrated excellent oxidative balance effects, pH-responsive release properties and antibacterial performances. Furthermore, the intracellular and in vivo studies confirmed that the NPs are capable of reducing oxidative damage to cells and significantly repairing tissue injury in mice with peritonitis. This work presents an effective method and idea for constructing biomass-based materials for the treatment of infection-induced diseases.